[:pb]
Authors: Pinto, L.S.S.; Silva, E.T.; Kaiser, C.R.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.
Source: Letters in Organic Chemistry, v. 13, p. 1-1, 2016.
Publisher: Bentham Science
Abstract
The isoniazid has been a key compound in first-line tuberculosis (TB) treatment, usually in combination with other drugs. Following on from the use of isoniazid itself, various derivatives of isoniazid have also been investigated as anti-TB agents and other diseases. This work aims to synthesize, multigram scale, salicylaldehyde isonicotinoyl hydrazone from isoniazid and salicylaldehyde, using ultrasound. Additionally, we have been interested in establishing a general, smaller-scale, ultrasonic driven synthesis of arylaldehyde isoniazid N-acylhydrazones, particularly for use in our biological studies.
Keywords: Green chemistry, isoniazid, N-acylhydrazone, SIH, bioactive, sonochemistry
Document Type: Research Article
DOI: 10.2174/1570178613666160824123827
Publication date: 1 de Janeiro de 2016
[:en]
Authors: Pinto, L.S.S.; Silva, E.T.; Kaiser, C.R.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.
Source: Letters in Organic Chemistry, v. 13, p. 1-1, 2016.
Publisher: Bentham Science
Abstract
The isoniazid has been a key compound in first-line tuberculosis (TB) treatment, usually in combination with other drugs. Following on from the use of isoniazid itself, various derivatives of isoniazid have also been investigated as anti-TB agents and other diseases. This work aims to synthesize, multigram scale, salicylaldehyde isonicotinoyl hydrazone from isoniazid and salicylaldehyde, using ultrasound. Additionally, we have been interested in establishing a general, smaller-scale, ultrasonic driven synthesis of arylaldehyde isoniazid N-acylhydrazones, particularly for use in our biological studies.
Keywords: Green chemistry, isoniazid, N-acylhydrazone, SIH, bioactive, sonochemistry
Document Type: Research Article
DOI: 10.2174/1570178613666160824123827
Publication date: 1 de Janeiro de 2016
[:]
