An eco-friendly, Hantzsch-Based, solvent-free approach to 2-aminothiazoles and 2-aminoselenazoles
Authors: Facchinetti, V.; Avellar, M.M.; Nery, A.C.S.; Gomes, C.R.B.; Vasconcelos, T.R.A.; De Souza, M.V.N. Source: Synthesis, v.48(3), p.437-440, 2016 Publisher: Thieme Abstract Reactions proceed to completion in a few seconds and products are obtained in moderate to excellent yields after easy workup. Moreover, the synthesis of 4-(2-amino-1,3-selenazol-4-yl)benzonitrile hydrobromide is reported for the first time. Keywords: […]
Eco-Friendly and Highly Efficient Synthesis, Including Multigram Synthesis, of Aldehyde Isonicotinoyl Hydrazones Using Sonochemistry
[:pb] Authors: Pinto, L.S.S.; Silva, E.T.; Kaiser, C.R.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L. Source: Letters in Organic Chemistry, v. 13, p. 1-1, 2016. Publisher: Bentham Science Abstract The isoniazid has been a key compound in first-line tuberculosis (TB) treatment, usually in combination with other drugs. Following on from the use of isoniazid itself, […]
Synthesis and Biological Activities of Camphor Hydrazone and Imine Derivatives
Authors: Silva, E.T.; Araújo S.A.; Moraes, A.M.; Souza, L.A.; Lourenço, M.C.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V. Source: Scientia Pharmaceutica, v. 84, p. 467-483, 2016 Publisher: Austrian Pharmaceutical Society Abstract Both sonochemical and classical methodologies have been employed to convert camphor, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one, C9H16C=O, into a number of derivatives including hydrazones, C9H16C=N-NHAr 3, imines, C9H16C=N-R 7, and […]
Quinoxaline Nucleus: A Promising Scaffold in Anti-cancer Drug Discovery
Authors: Pinheiro, A.C.; Mendonça, T.C.M.; De Souza, M.V.N. Source: Anti-Cancer Agents in Medicinal Chemistry, v. 16, p. 1339-1352, 2016 Publisher: Bentham Science Abstract Heterocyclic compounds are a class of substances, which play a critical role in modern drug discovery being incorporated in the structure of a large variety of drugs used in many different types of […]
N'-[(1E)-(5-Nitrofuran-2-yl)methylidene]thiophene-2-carbohydrazide: crystal structure and Hirshfeld surface analysis
Authors: Cardoso, L.N.F.; Nogueira, T.C.M.; Wardell, J.L.; Wardell, S.M.S.V.; De Souza, M.V.N.; Jotani, M.M.; Tiekink, E.R.T. Source: Acta Crystallographica Section E Crystallographic Communications, v. 72, p. 1025-1031, 2016 Publisher: International Union of Crystallography Abstract In the title carbohydrazide, C10H7N3O4S, the dihedral angle between the terminal five-membered rings is 27.4 (2)°, with these lying to the same […]
