Authors: De Souza, M.V.N.
Source: Mini-Reviews in Organic Chemistry, v. 2, p. 139-145, 2005.
Publisher: Bentham Science
Abstract
In recent years, furan-2(5H)-ones have attracted considerable attention as synthetic target. This subunit is present in a large number of natural products, which display a wide range of biological activities, and is present in a number of drugs with diverse biological activities, such as antifungal, antibacterial and anti-inflammatory. It can also be used as synthetic intermediate. This review describes recent synthetic methodologies for preparation of furan-2(5H)-ones, as well as their application in the total synthesis of natural products with this subunit.Keywords: furan-2(5h)-ones, biologic activity, natural products, syhthetic methodologies Document Type: Research Article DOI: http://dx.doi.org/10.2174/1570193053544427 Publication date: 1 de Janeiro de 2005
