Four nitrobenzaldehyde isonicotinoylhydrazones at 120K: four different supramolecular strucutures in two and three dimensions
Authors: De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Low, J.N. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C61, p. 683-689, 2005 Publisher: International Union of Crystallography Abstract The molecules of 2-nitrobenzaldehyde isonicotinoylhydrazone, C13H10N4O3, (I), are linked into a three-dimensional framework by a combination of one N-HN and three C-HO hydrogen bonds. In the […]
8-Methyl-5–oxo-5,6-dihydrodipyrido[1,2-a:3',2'-e]-pyrimidin-11-ium chloride trihydrate 120k
Authors: De Souza, M.V.N.; Vasconcelos, T.R.A.; Wardell, S.M.S.V.; Wardell, J.L.; Ferreira, M.L.; Howie, R.A. Source: Acta Crystallographica Section C, v. E61, p. 3579-3581, 2005. Publisher: International Union of Crystallography Abstract The difluorinated ring in 2,4-difluorobenzaldehyde isonicotinoylhydrazone, C13H9F2N3O, (I), is disordered over two sets of sites with unequal occupancy. The molecules of (I) are linked by a combination of […]
[pi]-Stacked hydrogen-bonded chains of rings in 2,4-difluorobenzaldehyde isonicotinoylhydrazone and hydrogen-bonded sheets in 2,3-dichlorobenzaldehyde isonicotinoylhydrazone
Authors: De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Ferreira, M.L.; Vasconcelos, T.R.A.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. 61, p. 617-620, 2005. Publisher: International Union of Crystallography Abstract The difluorinated ring in 2,4-difluorobenzaldehyde isonicotinoylhydrazone, C13H9F2N3O, (I), is disordered over two sets of sites with unequal occupancy. The molecules […]
Synthesis and Anti-Mycobacterial Activity of N'-[(E)-(Disubstituted- Phenyl)Methylidene]Isonicotino-Hydrazide Derivatives
Authors: De Souza, M.V.N.; Vasconcelos, T.R.A.; Mello, S.C.P.; Wardell, S.M.S.V.; Peralta, M.A.; Ferreira, B.; Henriques, M.G.M.O.; Neves Jr., I.; Lourenço, M.C.S. Source: Letters in Drug Design & Discovery, v. 2, p. 563-566, 2005. Publisher: Bentham Science Abstract A series of eight N-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium […]
Fuzeon, o primeiro medicamento de uma nova classe anti-HIV denominada inibidores de fusão
Authors: De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 86, n.3, p. 112-116, 2005. Publisher: Associação Brasileira de Farmacêuticos Abstract A sindrome da imunodeficiêÍncia adquirida (SIDA) é uma das mais temidas doenças no mundo. Uma promissora·área de pesquisa é baseada no estudo e obtenção de fármacos capazes de prevenir a entrada do vírus na […]
Rifampicina, um importante fármaco no combate à tuberculose
Authors: De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 86, n.3, p. 92-94, 2005. Publisher: Associação Brasileira de Farmacêuticos Abstract A tuberculose (TB) representa, nos dias atuais, um importante problema de sa ̇de pública mundial responsavel pela morte anual de 3 milhões de pessoas. Na luta contra a tuberculose, a rifampicina representa um importante […]
2-chloropyridine-3-carboxylic acid
Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Howie, R.A. Source: Acta Crystallographica. Section E, v. E61, p. 1347-1349, 2005. Publisher: International Union of Crystallography Abstract The molecules of the title compound, C6H4ClNO2, are almost completely planar. Hydrogen bonds of the form O-HN interconnect the molecules to form infinite chains, which are also planar and which are […]
Supramolecular structures of three isomeric 2-chloro-N-(nitrophenyl)nicotinamides
Authors: De Souza, M.V.N.; Vasconcelos, T.R.A.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C61, p. 204-208, 2005 Publisher: International Union of Crystallography Abstract Molecules of 2-chloro-N-(2-nitrophenyl)nicotinamide, C12H8ClN3O3, are linked by two C-HO hydrogen bonds into a chain of edge-fused (14) and (24) rings. In 2-chloro-N-(3-nitrophenyl)nicotinamide […]
New Fluoroquinolones: A Class of Potent Antibiotics
Authors: De Souza, M.V.N. Source: Mini – Reviews in Medicinal Chemistry, v. 5, n.11, p. 1009-1018, 2005. Publisher: Bentham Science Abstract The discovery of antibiotics opened a new era in the treatment against several pathogenic microorganisms that can disable or kill humans. The appearance of the fluoroquinolones (based on nalidixic acid, 4-quinolone-3-carboxylates), in the early […]
Furanones, Recent synthetic methodologies and your application in synthesis of natural products.
Authors: De Souza, M.V.N. Source: Mini-Reviews in Organic Chemistry, v. 2, p. 139-145, 2005. Publisher: Bentham Science Abstract In recent years, furan-2(5H)-ones have attracted considerable attention as synthetic target. This subunit is present in a large number of natural products, which display a wide range of biological activities, and is present in a number of […]
