[:pb]N-acylhydrazones containing thiophene nucleus: a new anticancer class[:]

[:pb]Authors: Cardoso, L. N. F.; Nogueira, T. C. M.; Rodrigues, F. A. R.; Oliveira, A. C. A.; Luciano, M. C. S.; Pessoa, C.; De Souza, M. V. N.
Source: Medicinal Chemistry Research, v. 26, p. 1605-1608, 2017
Publisher: Springer

Abstract

In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC₅₀) ranged from 0.82 to 12.90 μM. The compound (E)-N′-(2-hydroxy-3-methoxybenzylidene)thiophene-2-carbohydrazide displayed good cytotoxic activity in all cell lines (IC₅₀ = 0.82–5.36 μM) and yielded the best result in this series; therefore, it is an important lead compound in this new class.

Keywords: thienyl derivatives, N-acylhydrazones, cancer, antitumor

Document Type: Research Article

DOI: 10.1007/s00044-017-1832-y

Publication date: 23 de março de 2017

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