N-acylhydrazones containing thiophene nucleus: a new anticancer class

Authors: Cardoso, L.N.F.; Nogueira, T.C.M.; Rodrigues, F.A.R.; Oliveira, A.C.A.; Luciano, M.C.S.; Pessoa, C.O.; De Souza, M.V.N.


Abstract

In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC50) ranged from 0.82 to 12.90 μM. The compound (E)-N′-(2-hydroxy-3-methoxybenzylidene)thiophene-2-carbohydrazide displayed good cytotoxic activity in all cell lines (IC50 = 0.82–5.36 μM) and yielded the best result in this series; therefore, it is an important lead compound in this new class.


Keywords: Thienyl derivatives N-acylhydrazones Cancer Antitumor Document Type: Research ArticleDOI: http://dx.doi.org/10.1007/s00044-017-1832-yPublication date: 23 de Março de 2017[:en]

Abstract

In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC50) ranged from 0.82 to 12.90 μM. The compound (E)-N′-(2-hydroxy-3-methoxybenzylidene)thiophene-2-carbohydrazide displayed good cytotoxic activity in all cell lines (IC50 = 0.82–5.36 μM) and yielded the best result in this series; therefore, it is an important lead compound in this new class.


Keywords: Thienyl derivatives N-acylhydrazones Cancer Antitumor Document Type: Research ArticleDOI: http://dx.doi.org/10.1007/s00044-017-1832-yPublication date: March 23, 2017[:]

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