Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure-Activity Relationship (HQSAR) Modeling of Amino-Imino Tautomers
[:pb]Authors: Bispo, M.L.; Lima, C.H.S.; Cardoso, L.N.F.; Candea, A.; Bezerra, F.A.F.M.; Lourenço, M.C.; Henriques, M.; Alencastro, R.; Kaiser, C.R.; De Souza, M.V.N.; Albuqueurque, M. Source: PHARMACEUTICALS, v. 10, p. 52-68, 2017. Publisher: MDPI AG (Basel, Switzerland) Abstract In an ongoing research program for the development of new anti-tuberculosis drugs, we synthesized three series (A, B, […]
N-acylhydrazones containing thiophene nucleus: a new anticancer class
Authors: Cardoso, L.N.F.; Nogueira, T.C.M.; Rodrigues, F.A.R.; Oliveira, A.C.A.; Luciano, M.C.S.; Pessoa, C.O.; De Souza, M.V.N. Source: Medicinal Chemistry Research, v. 26, p. 1605-1608, 2017. Publisher: Springer International Publishing AG Abstract In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for […]
Synthesis and Evaluation of Anti-Tuberculosis and Anti-Cancer Activities of Hydrazones and N-Acylhydrazones by Using Sonochemistry, A New General Procedure
Authors: Pinto, L.S.; De Souza, M.V.N.; Kaiser, C.R. Source: Letters in Drug Design & Discovery, v. 14, p. 678-685, 2017. Publisher: Bentham Science Publishers Abstract Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report a new general and […]
Sonochemistry as a General Procedure for the Synthesis of Coumarins, Including Multigram Synthesis
Authors: Pinto, L.S.; De Souza. M.V.N. Source: Synthesis-Stuttgart, v. 49, p. 2677-2682, 2017. Publisher: Georg Thieme Verlag Stuttgart · New York Abstract This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was […]
Physicists Precisely Measure Proton’s Magnetic Moment
In a paper published in the journal Science, a team of physicists from Japan and Germany reports the most precise measurement ever made of the magnetic moment of the proton, allowing a fundamental comparison between matter and antimatter. The new result improves by a factor 11 the precision of the previous measurement, and is consistent […]
How bacteria survive in oxygen-poor environments
Biologists have revealed a mechanism by which bacterial cells in crowded, oxygen-deprived environments access oxygen for energy production, ensuring survival of the cell. The finding could explain how some bacteria, such as Pseudomonas aeruginosa (P. aeruginosa), are able to thrive in oxygen-poor environments like biofilms and resist antibiotics. P. aeruginosa biofilm infections are a leading […]
Antibiotics resistance: Researchers succeed to block genes of resistance
Ultimately, reducing the transfer of antibiotic-resistance plasmids could help preserve the potency of antibiotics. Antibiotics are commonly used around the world to cure diseases caused by bacteria. But as the World Health Organization and other international bodies have pointed out, the global increase of antibiotic resistance is a rapidly worsening problem. And since antibiotics are […]
Randomizing the news for science, transplanting genetically engineered skin, and the ethics of experimental brain implants
This week we hear stories on what to do with experimental brain implants after a study is over, how gene therapy gave a second skin to a boy with a rare epidermal disease, and how bone markings thought to be evidence for early hominid tool use may have been crocodile bites instead, with Online News Editor […]
Lightning can trigger nuclear reactions, creating rare atomic isotopes
Rare forms of atoms, like carbon-13, carbon-14, and nitrogen-15, have long been used to figure out the ages of ancient artifacts and probe the nuances of prehistoric food chains. The source of these rare isotopes? Complicated cascades of subatomic reactions in the atmosphere triggered by high-energy cosmic rays from outer space. Now, a team of […]
The world’s first dog pictures, and looking at the planet from a quantum perspective
About 8000 years ago, people were drawing dogs with leashes, according to a series of newly described stone carvings from Saudi Arabia. Online News Editor David Grimm talks with Sarah Crespi about reporting on this story and what it says about the history of dog domestication. Sarah also interviews physicist Brad Marston of Brown University […]
