Sonochemistry as a General Procedure for the Synthesis of Coumarins­, Including Multigram Synthesis

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Abstract

This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very effective on a multigram scale with a higher yield, higher amount of crystalline compound, and shorter reaction time compared with the compounds obtained using the classical procedures.

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Keywords: coumarins – sonochemistry – synthesis – multigram scale – smaller scale Publication date: 1 de Março de 2017 [:en]

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Abstract

This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very effective on a multigram scale with a higher yield, higher amount of crystalline compound, and shorter reaction time compared with the compounds obtained using the classical procedures.

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Keywords: coumarins – sonochemistry – synthesis – multigram scale – smaller scale Publication date: 1 de Março de 2017 [:]