Sonochemistry as a General Procedure for the Synthesis of Coumarins­, Including Multigram Synthesis

Authors: Pinto, L.S.; De Souza. M.V.N.


Abstract

This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very effective on a multigram scale with a higher yield, higher amount of crystalline compound, and shorter reaction time compared with the compounds obtained using the classical procedures.


Keywords: coumarins – sonochemistry – synthesis – multigram scale – smaller scale
 Document Type: Research Article
DOI: 10.1055/s-0036-1590201
Publication date: 1 de Março de 2017 [:en]

Abstract

This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very effective on a multigram scale with a higher yield, higher amount of crystalline compound, and shorter reaction time compared with the compounds obtained using the classical procedures.


Keywords: coumarins – sonochemistry – synthesis – multigram scale – smaller scale
 Document Type: Research Article
DOI: 10.1055/s-0036-1590201
Publication date: 1 de Março de 2017 [:]

Compartilhar publicação

Facebook
Twitter
Email
LinkedIn
WhatsApp

Deixe seu comentário

Compartilhar

Sobre a SSCDT

Nosso grupo de pesquisa está situado em Farmanguinhos e atualmente é o maior laboratório farmacêutico oficial vinculado ao Ministério da Saúde. Farmanguinhos produz mais de um bilhão de medicamentos por ano para os programas estratégicos do Governo Federal, além de atender demandas emergenciais no Brasil e no exterior.

posts Recentes