Authors: De Souza, M.V.N.; Vasconcelos, T.R.A.; Mello, S.C.P.; Wardell, S.M.S.V.; Peralta, M.A.; Ferreira, B.; Henriques, M.G.M.O.; Neves Jr., I.; Lourenço, M.C.S.
Source: Letters in Drug Design & Discovery, v. 2, p. 563-566, 2005.
Publisher: Bentham Science
Abstract
A series of eight N-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in mg/mL. Four compounds 2b-d and 2f exhibited a significant activity (0.6 mg/mL), when compared with first line drugs such as isoniazid (INH) and rifampin (RIP) and could be a good starting point to develop new lead compounds in the fight against multidrug resistant tuberculosis.Keywords: Isoniazid, tuberculosis, antimycobacterial activity Document Type: Research Article DOI: http://dx.doi.org/10.2174/157018005774479131 Publication date: 1 de Janeiro de 2005
