Authors: Pinheiro, A.C.; Kaiser, C.R.; Nogueira, T.C.M.; Carvalho, S.A.; Da Silva, E.F.; Feitosa, L.O.; Henriques, M.G.M.O.; Candea, A.L.P.; Lourenço, M.C.S.; De Souza, M.V.N.
Source: Medicinal Chemistry (Hilversum), v. 7, p. 611-623, 2011. Publisher: Bentham Science
Abstract
A series of 32 L-serinyl hydrazone derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv, being also evaluated their cell viabilities in non infected and infected macrophages with Mycobacterium bovis Bacillus Calmette-Guerin (BCG). The compounds 8c, 8e, 8h and 8i, were non-cytotoxic and exhibited an important minimum inhibitory concentration (MIC) activity between 25 and 100μg/mL, which can be compared with that of the tuberculostatic drug D-cicloserine (5-20μg/mL).
Keywords: BCG, D-cycloserine, hydrazone, L-cycloserine, L-serine, Mycobacterium, tuberculosis, L-serinyl hydrazone, tuberculostatic drug D-cicloserine, isoniazid and rifampinDocument Type: Research ArticleDOI: http://dx.doi.org/10.2174/157340611797928325Publication date: 1 de Janeiro de 2011
