Authors: Ferreira, M.L.; Vasconcelos, T.R.A.; Carvalho, E.M.; Lourenço, M.C.S.; Wardell, S.M.S.V.; Wardell, J.L.; Ferreira, V.F.; De Souza, M.V.N.
Source: Carbohydrate Research (Chicago, Ill.. Print), p. 2042-2047, 2009.
Publisher: Elsevier
Abstract
Six Schiff base derivatives of d-mannitol, 1,6-dideoxy-1,6-bis-{[(E)-arylmethylidene]amino}-d-mannitol (6: aryl = XC6H4: X = o-, m– and p– Cl or NO2), have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. All three nitro derivatives exhibit significant activities: activities of (6d: X = o-NO2), (6e: X = m-NO2) and (6f: X = p-NO2) are 12.5, 25.0 and 25.0 μg/mL, respectively. When compared with first line drugs, such as ethambutol, they can be considered as a good starting point to develop new lead compounds for the treatment of multidrug-resistant tuberculosis. Characterization of the new compounds 6 is generally achieved spectroscopically. The structure of compound 3 has been confirmed by X-ray crystallography.Keywords: d-Mannitol; Schiff bases; Antitubercular activity Document Type: Research Article DOI: http://dx.doi.org/10.1016/j.carres.2009.08.006 Publication date: 1 de Outubro de 2009
