Authors: Bispo, M.L.F.; Cardoso, L.N.F.; Lourenço, M.C.S.; Bezerra, F.A.F.M.; Soares, R.P.P.; Bertollo, C.M.; De Souza, M.V.N.
Abstract
A series of eight 7-chloro-4-alkoxyquinoline derivatives (2a-h) have been synthesized and their in vitro (antimycobacterial) activity against Mycobacterium tuberculosis was evaluated. Furthermore, all the active compounds were selected forevaluation of their cytotoxicities against the human hepatoma (HepG2) and the relative selectivity (selective index) of these compounds against M. tuberculosiscompared to HepG2 was calculated based on MLD50/MICratios. These biological results have been compared to a series of 7-chloro-4-aminoquinoline derivatives 1a-i, previously identified by our research group with the aim to provide important information about the structure-activity relationship of quinoline derivatives.Keywords:quinolone; tuberculosis; antimycobacterial activity;cytoxicity assays Document Type: Research Article DOI: http://dx.doi.org/10.13171/mjc.4.1.2015.19.02.10.18/desouza Publication date: 1 de Julho de 2015 [:en]
Abstract
A series of eight 7-chloro-4-alkoxyquinoline derivatives (2a-h) have been synthesized and their in vitro (antimycobacterial) activity against Mycobacterium tuberculosis was evaluated. Furthermore, all the active compounds were selected forevaluation of their cytotoxicities against the human hepatoma (HepG2) and the relative selectivity (selective index) of these compounds against M. tuberculosiscompared to HepG2 was calculated based on MLD50/MICratios. These biological results have been compared to a series of 7-chloro-4-aminoquinoline derivatives 1a-i, previously identified by our research group with the aim to provide important information about the structure-activity relationship of quinoline derivatives.
Keywords:quinolone; tuberculosis; antimycobacterial activity;cytoxicity assays Document Type: Research Article DOI: http://dx.doi.org/10.13171/mjc.4.1.2015.19.02.10.18/desouza Publication date: 1 de Julho de 2015 [:]
