Authors: Souza, L.A.; Da Silva, E.T.; Lourenço, M.C.S.; De Souza, M.V.N.
Source: Mediterranean Journal of Chemistry, v. 2(5), p. 648-657, 2014.
Publisher: Astucia Group
Abstract
This paper describes the synthesis and the in vitro antibacterial activity of a series of twelve substituted aryl-2-oxazolines against Mycobacterium tuberculosis. Seven compounds showed activity and two compounds exhibited a minimal inhibitory concentration (MIC) of 25 g/mL were not cytotoxic for the host cells in cell viability assay. These results could be a good starting point for the development of new antitubercular lead series based on this family of compounds.Keywords: 2-oxazolines, tuberculosis, antimycobacterial activity, L-amino acids. Document Type: Research Article DOI: http://dx.doi.org/10.13171/mjc.2.5.2014.06.01.23 Publication date: 1 de Janeiro de 2014
