Authors: De Souza, M.V.N.; Ferreira, M.L.; Cardoso, L.N.F.; Gonçalves, R.S.B.; Silva, E.T.; Lourenço, L.N.F.
Source: Derivatives. Letters in Drug Design & Discovery, v. 5, p. 137-140, 2008.
Publisher: Bentham Science
Abstract
The present article describes a series of eighteen N-[(E)-(hydroxy, methoxy and ethoxy substitutedphenyl) methylidene]isonicotinohydrazide derivatives, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μg/ml. Compounds 2a, 2d-f, and 2h exhibited a significant activity (0.31-1.25 μg/ml) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good start point to find new lead compounds in the fight against multi-drug resistant tuberculosis.Keywords: Tuberculosis, Multidrug-resistance, Isoniazid, Isonicotinohydrazides, Antimycobacterial activity, Alamar Blue assay Document Type: Research Article DOI: http://dx.doi.org/10.2174/157018008783928472 Publication date: 1 de Janeiro de 2008
