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Síntese de aminoálcoois derivados do D-manitol

Authors: De Souza, M.V.N.; Mello, S.C.P.; Ferreira, V.F. Source: Química Nova (Impresso), v. 31, p. 776-780, 2008 Publisher: Sociedade Brasileira de Química Abstract Aminoalcohols have found important applications in synthetic and medicinal chemistry, being used as chiral building blocks for the synthesis of many biologically active compounds. This class of compounds has been also used as […]

(+)-Calanolida A, um promissor produto natural no combate à replicação do vírus HIV e da bactéria Mycobacterium tuberculosis

Authors: De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 2, p. 129-134, 2008. Publisher: Associação Brasileira de Farmacêuticos Abstract Atualmente, a tuberculose (TB) continua sendo um grave problema de saúde pública mundial. Esta doença contagiosa é a causa mais comum de morbidade e uma das principais causas de morte em pessoas vivendo com HIV, […]

Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents

Authors: De Souza, M.V.N.; Ferreira, M.L.; Nogueira, T.C.M.; Gonçalves, R.S.B.; Peralta, M.A.; Lourenço, M.C.S.; Vicente, F.R.C. Source: Letters in Drug Design & Discovery, v. 5, p. 221-224, 2008. Publisher: Bentham Science Abstract The present article describes a series of eleven N-(alkyl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, […]

Validation of a capillary zone electrophoresis method for the determination of ciprofloxacin, gatifloxacin, moxifloxacin and ofloxacin in pharmaceutical formulations

Authors: De Souza, M.V.N.; Faria, A.F.; Oliveira, M.A.L. Source: Journal of the Brazilian Chemical Society (Impresso), v. 19, p. 389-396, 2008 Publisher: Sociedade Brasileira de Química Abstract An alternative capillary zone electrophoresis (CZE) method for the determination of ciprofloxacin (CPFLX), gatifloxacin (GTFLX), moxifloxacin (MFLX) and ofloxacin (OFLX) through a simple aqueous electrolyte system consisting of […]

Synthesis and Antitubercular Evaluation of N'-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide Derivatives

Authors: De Souza, M.V.N.; Ferreira, M.L.; Cardoso, L.N.F.; Gonçalves, R.S.B.; Silva, E.T.; Lourenço, L.N.F. Source: Derivatives. Letters in Drug Design & Discovery, v. 5, p. 137-140, 2008. Publisher: Bentham Science Abstract The present article describes a series of eighteen N-[(E)-(hydroxy, methoxy and ethoxy substitutedphenyl) methylidene]isonicotinohydrazide derivatives, which were synthesized and evaluated for their in vitro […]

Patterns of hydrogen bonding in mono- and disubstituted N-arylpyrazinecarboxamides.

Authors: Wardell, S.M.S.V.; De Souza, M.V.N.; Wardell, J.L.; Vasconcelos, T.A.; Ferreira, M.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section B, Structural Science, v. B, p. 84-100, 2008. Publisher: International Union of Crystallography Abstract The molecular and supramolecular structures of 18 N-arylpyrazinecarboxamides, Ar NHCO(C4H3N2), have been determined, including the stoichiometric monohydrate of N-(3-methoxyphenyl)pyrazinecarboxamide, and two polymorphs […]