Authors: De Souza, M.V.N.; Ferreira, M.L.; Nogueira, T.C.M.; Gonçalves, R.S.B.; Peralta, M.A.; Lourenço, M.C.S.; Vicente, F.R.C.
Source: Letters in Drug Design & Discovery, v. 5, p. 221-224, 2008.
Publisher: Bentham Science
Abstract
The present article describes a series of eleven N-(alkyl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μgmL. . The compounds 3g and 3k exhibited the respective activities of 25 and 50 μg/mL being a new class of compounds against tuberculosis.
Keywords: Tuberculosis, Multidrug-resistance, Thiophene, Thiopheneacetamides, Antimycobacterial activity, Alamar blue assay Document Type: Research Article DOI: http://dx.doi.org/10.2174/157018008784083965 Publication date: 1 de Janeiro de 2008
