Authors: Vicente, F.R.C.; Lourenço, M.C.; Henriques, M.G.M.O.; Candea, A.L.P.; Gonçalves, R.S.B.; Nogueira, T.C.M.; Ferreira, M.L.; De Souza, M.V.N.
Source: Bioorganic & Medicinal Chemistry Letters, v. 17, p. 6895-6898, 2007.
Publisher: Elsevier
Abstract
The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, and the activity expressed as the minimum inhibitory concentration (MIC) in μg/mL. The compounds 2, 3, 7, 8, 11, 12, 15, 16, and 20 exhibited activity between 25 and 100 μg/mL and could be a good start point to find new lead compounds in the fight against multidrug resistant tuberculosis.Keywords: Thiopheneacetamides; Tuberculosis; Antimycobacterial activity Document Type: Research Article DOI: http://dx.doi.org/10.1016/j.bmcl.2007.09.096 Publication date: 15 de Dezembro 2007
