[:pb]Authors: Pinto, Ligia S.; De Souza, M. V. N.; Kaiser, C. R.
Source: Letters in Drug Design & Discovery, v. 14, p. 678-685, 2017
Publisher: Bentham Science
Abstract
Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report a new general and efficient synthesis of these classes with different aromatic and heteroaromatic nucleus assisted by ultrasound and their respective anti-tuberculosis and anti-cancer activities.
Method: Derivatives 7-chloroquinoline 10 and 12 were the most promising compounds against cancer and TB, respectively.
Conclusion: Unfortunately all new hydrazones and N-acylhydrazones evaluated displayed no activity anti cancer and TB.
Keywords: hydrazones, N-acylhydrazones, sonochemistry, anti-tuberculosis and anti-cancer activities, drug discovery
Document Type: Research Article
DOI: 10.2174/1570180814666161121120414
Publication date: 2017
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