[:pb]Synthesis of benzylpiperazine derivatives containing the pyrazine moiety with potential activity against M. tuberculosis[:]

[:pb]Authors:Nery, A. C. S.; Gomes, C. R. B.; Pinheiro, A. C.; Facchinetti, V.; De Souza, M. V. N.
Source:Brazilian Journal of Health Review, v. 3, p. 15340-15354, 2020
Publisher: Brazilian Journal of Health Review


Abstract

Tuberculosis (TB), remains aglobalhealth challenge, despite the many efforts and recent advances in medicine and pharmacology. The World Health Organization estimates that 1.5million people worldwide died due to TB infection in 2018. In this context, the search for novel moleculesthat can offer higher potency, shorter treatment times, andfewerside effects is urgent. This work describes the synthesis ofeightnew benzylpiperazines containing the pyrazine moiety, with potential activity against TB. The structures were rationally planned usingthe molecular hybridization technique, from the drug pyrazinamide and the benzylpiperazine core.All proposed substances were obtained from a simple and reproductiblesyntheticprocess, in lowyields


Keywords: benzylpiperazine, pyrazine, tuberculosis

Document Type: Research Article

DOI: 10.34119/bjhrv3n5-312

Publication date: 27 de outubro de 2020[:]

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