[:pb]Monocyclic β -Lactam: A Review on Synthesis and Potential Biological Activities of a Multitarget Core[:]
[:pb]Authors: Leite, T. H.O.; Saraiva, M. F.; Pinheiro, A. C.; De Souza, M. V. N. Source: Mini-Reviews In Medicinal Chemistry, v. 20, p. 1653-1682, 2020 Publisher: Bentham science Abstract A monocyclic ring in their structure characterizes monobactams, a subclass of β-lactam antibiotics. Many of these compounds have a bactericidal mechanism of action and acts as […]
[:pb]Favipiravir in the Spotlight: In search of treatment against COVID-19[:]
[:pb]Authors: De Souza, M. V. N.; Facchinetti, V. […]
[:pb]A study of antituberculosis activities and crystal structures of (E)-2-[2-(arylidene)hydrazinyl]pyrimidine and (E)-N1-(arylidene)pyrimidine-2-carbohydrazide derivatives[:]
[:pb]Authors: Pinheiro, A. C.; Nogueira, Thaís C. M.; Da Costa, C. F.; Lourenço, C.; Low, J. N.; Wardell, J. L.; Wardell, Solange M. S. V.; De Souza, M. V. N. Source: Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences, v. 75, p. 1011-1028, 2020 Publisher: De Gruyter Abstract A study of the anti-tuberculosis activity […]
[:pb]Simultaneous separation of artesunate and mefloquine in fixed-dose combination tablets by CZE-UV[:]
[:pb]Authors: De Souza, J. C. Q. ; Chellini, P. R. ; Viçosa, A. L. ; De Souza, M. V. N. ; De Oliveira, M. A. L. Source: Analytical Methods, v. 12, p. 5709-5717, 2020 Publisher: Royal Society of Chemistry Abstract A novel method was proposed for simultaneous determination of artesunate (ATS) and mefloquine (MFQ) in […]
[:pb]1,3-Benzoxathiol-2-one and 1,3-Benzothiazole Compounds as Potential Anticancer and Antimicrobial Agents[:]
[:pb]Authors: Chazin, E. L.; Terra, L.; Moor, L. F. E.; Sanches, P. S.; Pinto, L. C.; Martins, T.; De Souza, M. V. N.; Gomes, C. R. B.; Montenegro, R. C.; Novais, J. S.; Carvalho, M. F.; Martins, F. J.; Figueiredo, A. M. S.; Joffily, A.; Castro, H. C.; Vasconcelos, T. R. A. Source: Revista Virtual […]
[:pb]The terpenic diamine GIB24 inhibits the growth of Trypanosoma cruzi epimastigotes and intracellular amastigotes, with proteomic analysis of drug-resistant epimastigotes[:]
[:pb]Authors: Azeredo, C. M. ; Saraiva, M. F. ; De Oliveira, M. R. ; Barbosa, G. ; De Almeida, M. V. ; De Souza, M. V. N. ; Soares, M. J. Source: Chemico-Biological Interactions, v. 330, p. 109165, 2020 Publisher: ScienceDirect Abstract The effect of N-geranyl-ethane-1,2-diamine dihydochloride (GIB24), a synthetic diamine, was assayed against different developmental forms […]
[:pb]Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity[:]
[:pb]Authors: Carvalho, K. I. M. ; Coutinho, D. S. ; Joca, H. C. ; Miranda, A. S. ; Cruz, J. S. ; Silva, E. T.; De Souza, M. V. N. ; Faria, R. X. ; Silva, P. M. R. E. ; Costa, J. C. S. ; Martins, M. A. Source: Frontiers in Pharmacology, v. 11, […]
[:pb]Synthesis and First-Time Assessment of o-Eugenol Derivatives against Mycobacterium tuberculosis[:]
[:pb]Authors: Moraes, A. M.; Da Silva, E. T. ; Wardell, J. L. ; De Souza, M. V. N. Source: Chemistry of Natural Compounds, v. 56, p. 633-638, 2020 Publisher: Springer Abstract In this work, we report the first-time assessment of o-eugenol, 6-allyl-2-methoxyphenol, and their selected derivatives, against Mycobacterium tuberculosis H37RV, using the MABA susceptibility test. […]
[:pb]In vitro Assessment of Camphor Hydrazone Derivatives as an Agent Against Leishmania amazonensis[:]
[:pb]Authors: Da Silva, Emerson Teixeira ; De Andrade, G. F. ; Araújo, A. S. ; Almeida, A. C.; Coimbra, E. S. ; De Souza, M. V. N. Source: Acta Parasitologica, v. 65, p. 203-207, 2020 Publisher: Springer Abstract Purpose: Due to serious problems with the treatment of leishmaniasis all around the world, here is an urgent need in the […]
[:pb]Synthesis of benzylpiperazine derivatives containing the pyrazine moiety with potential activity against M. tuberculosis[:]
[:pb]Authors:Nery, A. C. S.; Gomes, C. R. B.; Pinheiro, A. C.; Facchinetti, V.; De Souza, M. V. N. Source:Brazilian Journal of Health Review, v. 3, p. 15340-15354, 2020 Publisher: Brazilian Journal of Health Review Abstract Tuberculosis (TB), remains aglobalhealth challenge, despite the many efforts and recent advances in medicine and pharmacology. The World Health Organization […]
[:pb]A Review on Onychine and its Analogs: Synthesis and Biological Activity[:]
[:pb]Authors: Gomes, C. R.B.; de Souza, M. V.N.; Facchinetti, V. Source: Current Organic Synthesis, v. 17, p. 3-22, 2020 Publisher: Bentham Science Abstract Background: Onychine is a 4-azafluorenone alkaloid isolated from the Annonaceae family, in low concentrations. Onychine and its analogs exhibit a wide range of pharmacological activities such as antifungal, antibacterial, anticancer, and antimalarial. […]
[:pb]Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis[:]
[:pb]Authors: Antinarelli, L. M. R. ; De Souza, M. V. N.; Coelho, E. A. F. ; Lima, W. P. ; Coimbra, E. S. Source: Sociedade Brasileira De Medicina Tropical, v. 53, p. 1-5, 2020 Publisher: Revista da Sociedade Brasileira de Medicina Tropical Abstract Introduction: The drugs currently available for leishmaniasis treatment have major limitations. Methods: […]
