Recent Developments in Pleuromutilin Derivatives: A Promising Class Against Bacterial Respiratory Disease
Authors: Gonçalves, R.S.B.; De Souza, M.V.N. Source: Current Respiratory Medicine Reviews, v. 6, p. 91-101, 2010. Publisher: Bentham Science Abstract In the last three decades, an increasing number of pathogens resistant to common antibiotics have been a serious threat to public health worldwide. Pleuromutilin, its derivatives and others natural products are important in the fight […]
Evaluation of Substituted Benzaldehydes Against Mycobacterium tuberculosis
Authors: Ferreira, M.L.; Candea, A.L.P.; Henriques, M.G.M.O.; Lourenço, M.C.S.; Kaiser, C.R.; De Souza, M.V.N. Source: Letters in Drug Design & Discovery, v. 7, p. 754-758, 2010. Publisher: Bentham Science Abstract A series of 48 commercial benzaldehydes have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv, using the Alamar Blue susceptibility test […]
Benzyl N-[(S)-2-hydroxy-1-({[(E)-2-hydroxy-4-methoxybenzylidene]hydrazinyl}carbonyl)ethyl]carbamate
Authors: De Souza, M.V.N.; Pinheiro, A.C.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 66, p. 3253-3254, 2010. Publisher: International Union of Crystallography Abstract The shape of the title compound, C19H21N3O6, is curved with the conformation about the imine bond [1.291 (3) Å] being E. While the hydroxy-substituted benzene ring is almost coplanar with […]
N-(2-Chloroethyl)pyrazine-2-carboxamide
Authors: Lima, C.H.S.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 66, p. 2886-2887, 2010. Publisher: International Union of Crystallography Abstract In the title molecule, C7H8ClN3O, the pyrazine and amide groups are almost co-planar [N-C-C-N torsion angle = -2.4 (2) °], a conformation stabilized by an intramolecular N-HN hydrogen […]
N-(4-Bromophenyl)pyrazine-2-carboxamide
Authors: Ferreira, M.L.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 66, p. 2722-2723, 2010. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C11H8BrN3O, is close to planar (r.m.s. deviation of all 16 non-H atoms = 0.103 Å), a conformation stabilized by an intramolecular N-HN […]
Benzyl N-{(1S)-2-hydroxy-1-[N'-(2-nitrobenzylidene)hydrazinylcarbonyl]ethyl}carbamate
Authors: De Souza, M.V.N.; Pinheiro, A.C.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 66, p. 2023-2024, 2010. Publisher: International Union of Crystallography Abstract The carbamate and hydrazone groups in the title compound, C18H18N4O6, are approximately orthogonal [dihedral angle = 83.3 (4)°], and the carbonyl groups are effectively anti [O=CC=O torsion angle = […]
Synthesis and Antimycobacterial Activity of 2-aryl-3-(arylmethyl)-1,3-thiazolidin-4-ones
Authors: Gomes, C.R.B. ; Da Silva, M.M.; Facchinetti, V.; De Souza, M.V.N.; Vellasco, Jr., W.T.; Lourenço, M.C.S.; Cunico, W. Source: Letters in Drug Design & Discovery, v. 7, p. 353-358, 2010 Publisher: Bentham Science Abstract Fifteen new heterocyclic thiazolidinones have been synthesized from one-pot reactions of piperonylamine, arenealdehydes and mercaptoacetic acid. These compounds plus ten 2-aryl-3-(benzyl)-1,3-thiazolidin-4-ones […]
tert-Butyl N-[(S)-1-hydrazinecarbonyl-2-hydroxyethyl]carbamate
Authors: Pinheiro, A.C.; De Souza, M.V.N.; Tiekink, E.R.T.; Wardell, J.L.; Wardell, S.M.S.V. Source: Acta Crystallographica. Section E, v. 66, p. 994-994, 2010. Publisher: International Union of Crystallography Abstract In the title compound, C8H17N3O4, the dihedral angle between the hydrazinecarbonyl and carbamate groups is 44.94 (12)°, and the carbonyl groups are anti to each other. In the […]
Benzyl N-((S)-2-hydroxy-1-{N'-[(E)-2-methoxybenzylidene]hydrazinecarbonyl}ethyl)carbamate from synchrotron data
Authors: Pinheiro, A.C.; De Souza, M.V.N.; Tiekink, E.R.T.; Wardell, J.L.; Wardell, S.M.S.V. Source: Acta Crystallographica. Section E, v. 66, p. 1004-1005, 2010. Publisher: International Union of Crystallography Abstract A U-shaped conformation is found in the title compound, C19H21N3O5, with the benzene rings lying to the same side of the molecule; the dihedral angle between them is […]
Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives
Authors: Ferreira, M.L.; Candea, A.L.P.; Henriques, M.G.M.O.; Kaiser, C.R.; Lima, C.H.S.; De Souza, M.V.N. Source: Letters in Drug Design & Discovery, v. 7, p. 275-280, 2010. Publisher: Bentham Science Abstract A series of seventeen disubstituted N-acylhydrazone pyrazinecarbohydrazide (4-20) have been synthesized and evaluated for their cell viabilities, were compared to another monosubstituted derivatives previously synthesized […]
7-Chloro-4-[( E )-2-(4-methoxybenzylidene)hydrazin-1-yl]quinoline monohydrate
Authors: Ferreira, M.L.; De Souza, M.V.N.; Howie, R.A.; Tiekink, E.R.T.; Wardell, J.L.; Wardell, S.M.S.V Source: Acta Crystallographica. Section E, v. 66, p. 696-697, 2010. Publisher: International Union of Crystallography Abstract The organic molecule in the title hydrate, C17H14ClN3O·H2O, has a small but significant twist from planarity, as seen in the dihedral angle of 12.10 (17)° between the […]
Synthesis and antimycobacterial evaluation of N -[(E)-(monosubstituded-benzylidene)]-2-pyrazinecarbohyrazide derivatives
Authors: Vergara, F.M.F.; Lima, C.H.S.; Henriques, M.G.M.O.; Candea, A.L.P.; Lourenço, M.C.S.; Ferreira, M.L.; Kaiser, C.R.; De Souza, M.V.N. Source: European Journal of Medicinal Chemistry, v. 44, p. 4954-4959, 2009. Publisher: Elsevier Abstract The present article describes a series of twenty-six N′-[(E)-(monosubstituted-benzylidene)]-2-pyrazinecarbohydrazide (4–29), which were synthesized and evaluated for their cell viabilities in non infected and […]
