Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives
Authors: Cardoso, S.H.; Assis, J.V.; Almeida, M.V.; Lourenço, M.C.S.; Vicente, F.R.C.; De Souza, M.V.N. Source: Química Nova (Impresso), v. 32, p. 1557-1560, 2009 Publisher: Sociedade Brasileira de Química Abstract A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using […]
A natureza no combate à tuberculose
Authors: De Souza, M.V.N.; Cardoso, S.H.; Riente, R.R. Source: Revista Brasileira de Farmácia, v. 90, p. 95-100, 2009. Publisher: Associação Brasileira de Farmacêuticos (ABF) Abstract Atualmente, a tuberculose (TB) tornou-se novamente um sério problema de saúde pública mundial,sendo responsável pela morte de 1,7 milhões de pessoas a cada ano. O ressurgimento da TB pode ser […]
A tuberculose e o desenvolvimento de novos tuberculostáticos em Far‐Manguinhos (FIOCRUZ) no Rio de Janeiro
Authors: De Souza, M.V.N. Source: Revista Virtual de Química, v. 1, p. 9-16, 2009. Publisher: Sociedade Brasileira de Química Abstract O presente artigo tem como objetivo apresentar a importância atual da tuberculose no cenário da Saúde Pública Mundial, bem como alguns trabalhos desenvolvidos na busca de novos tuberculostáticos em Far-Manguinhos (FIOCRUZ) no Rio de Janeiro. […]
Utilização do D-manitol em síntese orgânica
Authors: De Souza, M.V.N.; Mello, S.C.P.; Ferreira, V.F. Source: Química Nova (Impresso), v. 32, p. 441-452, 2009. Publisher: Sociedade Brasileria de Química Abstract D-mannitol is used in several fields including food, pharmaceuticals, cosmetics and textiles being an important carbohydrate found widespread in nature. Due to its chirality, it is largely used in organic synthesis with […]
Synthesis and Biological Evaluation of N,N'-di(thiopheneacetyl)diamines Series as Antitubercular Agents
Authors: De Souza, M.V.N.; Lourenço, M.C.S.; Peralta, M.A.; Gonçalves, R.S.B.; Nogueira, T.C.M.; Lima, C.H.S.; Ferreira, M.L.; Silva, E.T. Source: Phosphorus, Sulfur and Silicon and the Related Elements, v. 183, p. 2990-2997, 2008. Publisher: Taylor & Francis Group Abstract The series of new N,N′-di(thiopheneacetyl)diamines derivatives, 8–17, were synthesized and evaluated for their in vitro antibacterial activity […]
Lamivudine, an important drug in aids treatment
Authors: Vasconcelos, T.R.A.; Ferreira, M.L.; Gonçalves, R.S.B.; Silva, E.T.; De Souza, M.V.N. Source: Journal of Sulfur Chemistry, v. 29, p. 559-571, 2008. Publisher: Taylor & Francis Group Abstract Lamivudine, an L-nucleoside, has been considered the cornerstone of antiretroviral therapy programs considering its favorable efficacy, convenient dosing, and safety profile. The low incidence of side effects in […]
Optimization of an electrolyte system for analysis of ethambutol in pharmaceutical formulations by capillary zone electrophoresis using complexation with copper(II)
Authors: De Souza, M.V.N.; Faria, A.F.; Bruns, R.E.; Oliveira, M.A.L. Source: Journal of Chromatography (Print), v. 1202, p. 224-228, 2008. Publisher: Elsevier Abstract An alternative methodology for the determination of ethambutol by capillary zone electrophoresis (CZE) under direct UV detection at 262 nm, using acetic acid/sodium acetate buffer solution (pH 4.6) containing copper(II) sulphate to form the […]
Compounds containing oxazolidinone, triazole and macrolide groups in the treatment of mycobacterial infections
Authors: De Souza, M.V.N. Source: Expert Opinion on Therapeutic Patents, v. 18, p. 1101-1105, 2008. Publisher: Taylor & Francis Group Abstract Nowadays fixed-dose combinations and me-too drugs are important strategies in the fight against multi-drug resistant microorganisms and other kind of diseases and have been studied by several pharmaceutical companies. Considering this fact the present […]
Synthesis, Antimalarial Activity, and Intracellular Targets of MEFAS, a New Hybrid Compound Derived from Mefloquine and Artesunate
Authors: Varotti, F.P.; Botelho, A.C.C.; Andrade, A.A.; De Paula, R.C.; Fagundes, E.M.S.; Valverde, A.; Mayer, L.M.U.; Mendonça, J.S.; De Souza, M.V.N.; Boechat, N.; Krettli, A.U. Source: Antimicrobial Agents and Chemotherapy, v. 52, p. 3868-3874, 2008. Publisher: American Society for Microbiology Abstract A new synthetic antimalarial drug, a salt derived from two antimalarial molecules, mefloquine (MQ) […]
Synthesis and Biological Aspects of Mycolic Acids: An Important Target Against Mycobacterium tuberculosis
Authors: De Souza, M.V.N.; Ferreira, M.L.; Pinheiro, A.C.; Saraiva, M.F.; Almeida, M.V.; Valle, M.S. Source: The Scientific World Journal, v. 8, p. 720-751, 2008 Publisher: Hindawi Publishing Corporation Abstract Mycolic acids are an important class of compounds, basically found in the cell walls of a group of bacteria known as mycolata taxon, exemplified by the […]
Formation of N-Acyl-N,N′-dicyclohexylureas from DCC and Arenecarboxylic Acids in the Presence of Hydroxybenzotriazole in CH2Cl2 at Room Temperature
Authors: De Souza, M.V.N.; Kaiser, C.R.; Pinheiro, A.C.; Wardell, S.M.S.V.; Wardell, J.L. Source: Journal of Chemical Research, 468-472, 2008 Publisher: Science Reviews 2000 Ltd Abstract The syntheses of N-acyl-N,N′-dicyclohexylureas from 1,3-dicyclohexylcarbodiimide and arenecarboxylic acids [p-XC6H4CO2H (X = H or NO2), 2-, 3- or 4-pyridinecarboxylic acid and pyrazinecarboxylic acid] in the presence of hydroxybenzotriazole in CH2Cl2 […]
Synthesis and anti-mycobacterial activity of of (E)-N-(monosubstituted-benzylidene)isonicotinohydrazide derivatives
Authors: Lourenço, M.C.; Ferreira, M.L.; De Souza, M.V.N.; Peralta, M.A.; Vasconcelos. T.A.; Henriques, M.G.M.O. Source: European Journal of Medicinal Chemistry, v. 43, p. 1344-1347, 2008. Publisher: Elsevier Abstract A series of 22 (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and […]
