Synthesis and characterization of n-hydroxyalkyl and oxazolinyl ethionamide derivatives
Authors: Cardoso, S.H.; Almeida, M.V.; Assis, J.V.; Diniz, R.; Speziali, N.L.; De Souza, M.V.N. Source: Journal of Sulfur Chemistry, v. 29, p. 145-149, 2008. Publisher: Taylor & Francis Group Abstract Multidrug-resistant tuberculosis (MDR-TB) is a serious problem worldwide, especially in people living with human immunodeficiency virus. In considering the MDR-TB problem, ethionamide (ETH) is a […]
Synthesis and antispasmodic activity of lidocaine derivatives endowed with reduced local anesthetic action
Authors: Costa, J.C.S.; Neves, J.S.; De Souza, M.V.N.; Siqueira, R.A.; Romeiro, N.C.; Boechat, N.; Silva, P.M.; Martins, M.A. Source: Bioorganic & Medicinal Chemistry Letters, v. 18, p. 1162-1166, 2008. Publisher: Elsevier Abstract The present structure-activity relationship (SAR) study focused on chemical modifications of the structure of the local anesthetic lidocaine, and indicated analogues having reduced […]
Synthesis and antimycobacterial evaluation of new trans-cinnamic acid hydrazide derivatives
Authors: Carvalho, S.A.; Silva, E.F.; De Souza, M.V.N.; Lourenço, M.C.S.; Vicente, F.R.C. Source: Bioorganic & Medicinal Chemistry Letters, v. 18, p. 538-541, 2008. Publisher: Elsevier Abstract In this work, we report the synthesis and the antimycobacterial evaluation of new trans-cinnamic acid derivatives of isonicotinic acid series (5) and benzoic acid series (6), designed by exploring […]
Síntese de aminoálcoois derivados do D-manitol
Authors: De Souza, M.V.N.; Mello, S.C.P.; Ferreira, V.F. Source: Química Nova (Impresso), v. 31, p. 776-780, 2008 Publisher: Sociedade Brasileira de Química Abstract Aminoalcohols have found important applications in synthetic and medicinal chemistry, being used as chiral building blocks for the synthesis of many biologically active compounds. This class of compounds has been also used as […]
(+)-Calanolida A, um promissor produto natural no combate à replicação do vírus HIV e da bactéria Mycobacterium tuberculosis
Authors: De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 2, p. 129-134, 2008. Publisher: Associação Brasileira de Farmacêuticos Abstract Atualmente, a tuberculose (TB) continua sendo um grave problema de saúde pública mundial. Esta doença contagiosa é a causa mais comum de morbidade e uma das principais causas de morte em pessoas vivendo com HIV, […]
Estreptomicina, um fármaco que mudou a história da humanidade, salvando-a da Tuberculose
Authors: De Souza, M.V.N.; Ferreira, M.L. Source: Ciência Hoje, v. 42, p. 36-41, 2008. Publisher: INSTITUTO CIÊNCIA HOJE Abstract None Keywords: None Document Type: Review Article DOI: None Publication date: 1 de Janeiro de 2008
Synthesis and Biological Evaluation of N-(Alkyl)-2-Thiophen-2-Ylacetamides Series As A New Class of Antitubercular Agents
Authors: De Souza, M.V.N.; Ferreira, M.L.; Nogueira, T.C.M.; Gonçalves, R.S.B.; Peralta, M.A.; Lourenço, M.C.S.; Vicente, F.R.C. Source: Letters in Drug Design & Discovery, v. 5, p. 221-224, 2008. Publisher: Bentham Science Abstract The present article describes a series of eleven N-(alkyl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, […]
Validation of a capillary zone electrophoresis method for the determination of ciprofloxacin, gatifloxacin, moxifloxacin and ofloxacin in pharmaceutical formulations
Authors: De Souza, M.V.N.; Faria, A.F.; Oliveira, M.A.L. Source: Journal of the Brazilian Chemical Society (Impresso), v. 19, p. 389-396, 2008 Publisher: Sociedade Brasileira de Química Abstract An alternative capillary zone electrophoresis (CZE) method for the determination of ciprofloxacin (CPFLX), gatifloxacin (GTFLX), moxifloxacin (MFLX) and ofloxacin (OFLX) through a simple aqueous electrolyte system consisting of […]
Synthesis and Antitubercular Evaluation of N'-[(E)-(hydroxy, methoxy and ethoxy-substituted-phenyl) Methylidene]isonicotinohydrazide Derivatives
Authors: De Souza, M.V.N.; Ferreira, M.L.; Cardoso, L.N.F.; Gonçalves, R.S.B.; Silva, E.T.; Lourenço, L.N.F. Source: Derivatives. Letters in Drug Design & Discovery, v. 5, p. 137-140, 2008. Publisher: Bentham Science Abstract The present article describes a series of eighteen N-[(E)-(hydroxy, methoxy and ethoxy substitutedphenyl) methylidene]isonicotinohydrazide derivatives, which were synthesized and evaluated for their in vitro […]
Patterns of hydrogen bonding in mono- and disubstituted N-arylpyrazinecarboxamides.
Authors: Wardell, S.M.S.V.; De Souza, M.V.N.; Wardell, J.L.; Vasconcelos, T.A.; Ferreira, M.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section B, Structural Science, v. B, p. 84-100, 2008. Publisher: International Union of Crystallography Abstract The molecular and supramolecular structures of 18 N-arylpyrazinecarboxamides, Ar NHCO(C4H3N2), have been determined, including the stoichiometric monohydrate of N-(3-methoxyphenyl)pyrazinecarboxamide, and two polymorphs […]
Synthesis and biological evaluation of N-(aryl)-2-thiophen-2-ylacetamides series as a new class of antitubercular agents
Authors: Vicente, F.R.C.; Lourenço, M.C.; Henriques, M.G.M.O.; Candea, A.L.P.; Gonçalves, R.S.B.; Nogueira, T.C.M.; Ferreira, M.L.; De Souza, M.V.N. Source: Bioorganic & Medicinal Chemistry Letters, v. 17, p. 6895-6898, 2007. Publisher: Elsevier Abstract The present article describes a series of 21 N-(aryl)-2-thiophen-2-ylacetamides, which were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis, […]
Synthesis and antitubercular activity of lipophilic moxifloxacin and gatifloxacin derivatives
Authors: Almeida, M.V.; Saraiva, M.F.; De Souza, M.V.N.; Costa, C.F.; Vicente, F.R.C.; Lourenço, M.C. Source: Bioorganic & Medicinal Chemistry Letters, v. 17, p. 5661-5664, 2007 Publisher: Elsevier Abstract Fluoroquinolone (FQ) has a broad spectrum of activity against several bacteria, mycobacteria, parasites, and other diseases. Moxifloxacin and gatifloxacin are a new generation of fluoroquinolone agents with […]
