In vitro activity of ciprofloxacin, ofloxacin, levofloxacin, sparfloxacin and gatifloxacin against multidrug-resistant Mycobacterium tuberculosis in Rio de Janeiro Brazil.
Authors: Lourenço, M.C.S.; Neves Jr., I.; De Souza, M.V.N. Source: Médecine et Maladies Infectieuses, v. 37, p. 295-298, 2007. Publisher: Elsevier Abstract None Keywords: Mycobacterium tuberculosis; Fluoroquinolones; Multi drug resistance Document Type: Research Article DOI: http://dx.doi.org/10.1016/j.medmal.2007.03.011 Publication date: 1 de Maio de 2007
Synthesis of 2-mercaptobenzothiazole and 2-mercaptobenzimidazole derivatives condensed with carbohydrates as a potential antimicrobial agents
Authors: Almeida, M.V.; Cardoso, S.H.; Assis, J.V.; De Souza, M.V.N. Source: Journal of Sulfur Chemistry, v. 28, p. 17-22, 2007. Publisher: Taylor & Francis Group Abstract The thiazole and imidazole nucleus, as well as carbohydrates are important classes of compounds found in many natural and synthetic products with a wide range of biological activities. Due […]
Enhanced activity of mefloquine and artesunic acid against Plasmodium falciparum in vitro and P. berghei in mice by combination with ciprofloxacin
Authors: Andrade, A.A.; Freitas, I.O De Souza, M.V.N.; Vasconcelos, T.R.A.; Boechat, N.; Krettli, A.U. Source: European Journal of Pharmacology, v. 558, p. 194-198, 2007. Publisher: Elsevier Abstract The antimalarial activity of combinations of mefloquine or artesunic acid with ciprofloxacin and other synthetic fluoroquinolone was tested in vitro against Plasmodium falciparum using a strain (BHz26/86) partially resistant […]
4-Cyanobenzaldehyde isonicotinoyl-hydrazone monohydrate: a three-dimensional hydrogen-bonded framework structure
Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C63, p. 0166-0168, 2007. Publisher: International Union of Crystallography Abstract In the title compound, C14H10N4O·H2O, the molecular components are linked into a three-dimensional framework by three hydrogen bonds, one each of the O-HO, O-HN and […]
Thalidomide Analogs from Diamines: Synthesis and Evaluation as Inhibitors of TNF-α Production
Authors: De Souza, M.V.N.; Almeida, M.V.; Teixeira, F.M.; Amarante, G.W.; Alves, C.C.S.; Cardoso, S.H.; Mattos, A.M.; Ferreira, A.P.; Teixeira, H.C. Source: Chemical and Pharmaceutical Bulletin, v. 55, p. 223-226, 2007. Publisher: The Pharmaceutical Society of Japan Abstract Fourteen thalidomide analogs bearing two phthalimido units were prepared in high yields (83—94%) by condensation of different diamines […]
Oxazolidinonas: uma nova classe de compostos no combate à tuberculose
Authors: Kaiser, C.R.; Cunico, W.; Pinheiro, A.C.; Oliveira, A.G.; De Souza, M.V.N. Source: Revista Brasileira de Farmacia, v. 88, p. 83-88, 2007. Publisher: Associação Brasileira de Farmacêuticos Abstract Atualmente,a tuberculose (TB) é um grave problema de saúde pública mundial. Essa doença contagiosa é causada pela bactéria Mycobacterium tuberculosis, que ataca principalmente os pulmõıes sendo responsável a […]
Halogen Dance Reaction and its Application in Organic Synthesis.
Authors: De Souza, M.V.N. Source: Current Organic Chemistry, v. 11, p. 637-646, 2007. Publisher: Bentham Science Abstract Halogen dance (HD) reaction is an important tool in modern organic chemistry. This reaction is defined as halogen migration induced by bases, normally in aromatic and heteroaromatic systems. It is successfully applied in aromatic and different classes of […]
Problemas relacionados ao tratamento da tuberculose em pacientes com problemas hepáticos e renais
Authors: Ferreira, M.L.; Nogueira, T.C.M.; De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 88, p. 125-131, 2007. Publisher: Associação Brasileira de Farmacêuticos Abstract Atualmente, a tuberculose (TB) se tornou um problema de saúde pública mundial, afetando todas as idades. Essa doença infectocontagiosa, transmitida pelo ar, cujo agente etiológico é o Mycobacterium tuberculosis é responsável por […]
Synthesis and Antimicrobial Activity of Pyridine Derivatives Substituted at C-2 and C-6 Positions
Authors: Almeida, M.V.; De Souza, M.V.N.; Barbosa, N.; Amarante, G.W.; Cardoso, S.H. Source: Letters in Drug Design & Discovery, v. 4, p. 149-153, 2007 Publisher: Bentham Science Abstract A series of C-2 and C-6 substituted pyridines was synthesized and evaluated in vitro against Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans and Candida albicans. Most of compounds […]
Three isomeric 1-(2-chloronicotinoyl)-2-(nitrophenyl)hydrazines, including three polymorphs of 1-(2-chloronicotinoyl)-2-(2-nitrophenyl)hydrazine:hydrogen-bonded supramolecular structures intwo and three dimensions
Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section B, Structural Science, v. B63, p. 101-110, 2007. Publisher: International Union of Crystallography Abstract 1-(2-Chloronicotinoyl)-2-(2-nitrophenyl)hydrazine, C12H9ClN4O3, crystallizes in three polymorphic forms, two monoclinic forms in space groups Cc (Ia) and P21 (Ib), and an orthorhombic form in space group […]
N-(5-Chloro-2-nitrobenzoyl)-N´isonicotinoylhydrazine: a three-dimensional framework containing four types of hydrogen bond
Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section E, v. E63, p. 230-232, 2007. Publisher: International Union of Crystallography Abstract The title compound, C13H9ClN4O4, crystallizes with Z‘ = 2, and the two molecules have markedly different conformations. The molecules are linked into a three-dimensional framework by a […]
2,3-Dimethoxybenzaldehyde isonicotinoylhydrazone chloroform monosolvate, and the mono- and dihydrates of 3,4,5-trimethoxybenzaldehyde isonicotinoylhydrazone: hydrogen-bonded supramolecular strucutures in one, two and three dimensions
Authors: Peralta, M.A.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C63, p. 68-72, 2007. Publisher: International Union of Crystallography Abstract In 2,3-dimethoxybenzaldehyde isonicotinoylhydrazone chloroform monosolvate, C15H15N3O3·CHCl3, the hydrazone molecules are linked by a combination of N-HN and C-HN hydrogen bonds into chains […]
