3-Nitrobenzaldehyde isonicotinoylhydrazone monohydrate redetermined at 120 K
Authors: Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C.; De Souza, M.V.N. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C63, p. 42-44, 2007. Publisher: International Union of Crystallography Abstract In the title compound, C13H10N4O3·H2O, the molecular components are linked into complex sheets by a combination of four types of hydrogen bonds. Keywords: None […]
Supramolecular structures in N-isonicotinoyl arylaldehydehydrazones: multiple hydrogen-bonding modes in series of geometric isomers
Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section B, Structural Science, v. B63, p. 879-895, 2007. Publisher: International Union of Crystallography Abstract Sixteen N-isonicotinoyl arylaldehydehydrazones, NC5H4CONHN=CHC6H4R, have been studied and the structures of 14 of them have been determined, including the unsubstituted parent compound with R = H, […]
Produtos Naturais em Fase Avançada de Testes Clínicos no Tratamento contra o Câncer
Authors: De Souza, M.V.N.; Pinheiro, A.C.; Ferreira, M.L.; Gonçalves, R.S.B.; Lima, C.H.S. Source: Revista Fitos (ALANAC), v. 3, p. 25-42, 2007. Publisher: FIOCRUZ Abstract Atualmente, os produtos naturais representam uma inestimável fonte de substâncias químicas tendo um importante papel no tratamento do câncer. Devido à importância da natureza como fonte de novos candidatos a fármacos no […]
Tuberculose Infantil: Tratamento e problemas relacionados
Authors: Ferreira, M.L.; Gonçalves, R.S.B.; Nogueira, T.C.M.; Rocha, L.C.; De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 88, p. 38-44, 2007. Publisher: Associação Brasileira de Farmacêuticos Abstract Em nossos dias, Tuberculose (TB) se tornou novamente um grave problema de saúde pública mundial, tendo sido ainda declarado pela Organização Mundial de Súde (OMS), um problema […]
Evaluation of anti-tubercular activity of nicotinic and isoniazid analogues
Authors: Lourenço, M.C.S.; De Souza, M.V.N.; Pinheiro, A.C.; Ferreira, M.L.; Gonçalves, R.S.B.; Nogueira, T.C.M.; Peralta, M.A. Source: ARKIVOC, v. XV, p. 181-191, 2007. Publisher: Arkat USA, Inc. Abstract Several nicotinic and isoniazid derivatives, most of them containing nitro groups were synthesized by our group, and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis […]
Simultaneous separation of five fluoroquinolone antibiotics
Authors: De Oliveira, M.A.L.; Faria, A.F.; Almeida, M.V.; De Souza, M.V.N. Source: Analytica Chimica Acta, v. 579, p. 185-192, 2006. Publisher: Elsevier Abstract A novel methodology has been developed for simultaneous separation of ciprofloxacin (CPFLX), gatifloxacin (GTFLX), levofloxacin (LVFLX), moxifloxacin (MFLX) and sparfloxacin (SPFLX) fluoroquinolone antibiotics (FQs), using capillary zone electrophoresis (CZE) with UV detection […]
Evaluation of antimalarial and fluoroquinolone combination against Plasmodium falciparum in vitro
Authors: Boechat, N.; Krettli, A.U.; Soares, R.P.P. ; De Souza, M.V.N.Vasconcelos, T.R.A. Source: International Journal of Antimicrobial Agents, v. 28, p. 270-272, 2006. Publisher: Elsevier Abstract None Keywords: None Document Type: Research Article DOI: http://dx.doi.org/10.1016/j.ijantimicag.2006.06.003 Publication date: 1 de Setembro de 2006
Comparison of the reactivities of 2-mercaptoaniline and 2-hydroxyaniline with 2-chloronicotinoyl chloride
Authors: De Souza, M.V.N.; Vasconcelos, T.R.A.; Wardell, S.M.S.V.; Wardell, J.L.; Carvalho, E.M. Source: Journal of Sulfur Chemistry (Print), v. 27, n.3, p. 193-202, 2006. Publisher: Taylor & Francis Group Abstract The reaction between equimolar 2-chloronicotinoyl chloride and 2-mercaptopyridine in ClCH2CH2Cl, after 30 minutes refluxing in ClCH2CH2Cl solution, produced pyrido[2,3,b][1,5]benzothiazepin-5(H)one 7, and 6-[3-(2-benzothiazolyl)pyridin-2-yl)thio]-N-[3-(2-benzothiazolyl)pyridin-2-yl]aniline 8. In contrast, […]
Recent methodologies mediated by sodium borohydride in the reduction of different classes of compounds
Authors: De Souza, M.V.N. ; Vasconcelos, T.R.A. Source: Applied Organometallic Chemistry, v. 20, p. 798-810, 2006. Publisher: John Wiley & Sons, Inc. Abstract Reduction is a fundamental transformation in organic synthesis. Since its discovery by Brown and co-workers, sodium borohydride is the most frequently hydride used in reduction processes. Owing to the importance of this reagent in […]
Marine Natural Products Against Tuberculosis
Authors: De Souza, M.V.N. Source: The Scientific World Journal, v. 6, p. 847-861, 2006. Publisher: Hindawi Publishing Corporation Abstract Natural products represent an outstanding source of compounds that play an important role in the treatment of human diseases. Due to the importance of nature as a source of new drug candidates, the aim of this review […]
Experimental and theoretical structure characterization of two isoniazid derivatives: 2,4-difluoro-N´-isonicotinoylbenzohydrazide and 2,4-dichloro-N´-isonicotinoylbenzohydrazide hydrochloride
Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Ferreira, M.L.; Wardell, J.L.; Vasconcelos, T.R.A.; Mascarenhas, Y.P.; Ellena, J.; Silvas Jr., F.P. Source: Journal of Molecular Structure, v. 788, p. 63-71, 2006. Publisher: Elsevier Abstract An X-ray and a theoretical study of the structure of the isoniazid derivatives, 2,4-difluoro-N′-isonicotinoylbenzohydrazide, 3, and 2,4-dichloro-N′-isonicotinoylbenzohydrazide hydrochloride, [4H+, Cl−, 2(H2O)], are reported. […]
Current status and future prospects for new therapies for pulmonary tuberculosis
Authors: De Souza, M.V.N. Source: Current Opinion in Pulmonary Medicine, v. 12, n.3, p. 167-171, 2006. Publisher: Wolters Kluwer Health, Inc. Abstract Purpose of review: Nowadays tuberculosis is becoming a worldwide problem, and according to the World Health Organization, which declared tuberculosis a global health emergency in 1993, each year 8 million people worldwide develop the […]
