Analysis of Omega 3 Fatty Acid in Natural and Enriched Chicken Eggs by Capillary Zone Electrophoresis
Authors: Porto, B.L.S.; De Souza, M.V.N.; De Oliveira, M.A.L. Source: Analytical Sciences, v. 27, p. 541, 2011. Publisher: The Japan Society for Analytical Chemistry Abstract Qualitative differentiation between natural and enriched chicken eggs through omega (ω) 3 fatty acid profiles by capillary zone electrophoresis (CZE) under direct UV detection at 200 nm is proposed. The […]
S-1-[N-(Benzylidene)hydrazinylcarbonyl]-2-hydroxyethylcarbamate esters: layered structures created from H•••O ( = N,O) hydrogen-bonds
Authors: Howie, R.A.; De Souza, M.V.N.; Pinheiro, A.C.; Kaiser, C.R.; Wardell, J.L.; Wardell, S.M.S.V. Source: Zeitschrift für Kristallographie, p. 110302053145056-491, 2011 Publisher: De Gruyter Abstract The molecular structures of tert-butyl (S)-2-hydroxy-[N-(substituted-benzylidene)hydrazinyl-carbonyl]-ethylcarbamates, C15H20N3O4X (3: X = H, o-OH, o-NO2, m-NO2 and p-CN), derived from L-serine, are formally rather similar. Despite the variation in substituent, X, tricälinic […]
Ethambutol analysis by copper complexation in pharmaceutical formulations: spectrophotometry and crystal structure
Authors: Faria, A.F.; Marcellos, L.F.; Vasconcelos, J.P.; De Souza, M.V.N.; Do Carmo, W.R.; Diniz, R.; Oliveira, M.A.L. Source: Journal of the Brazilian Chemical Society (Impresso), v. 22, p. 867-874, 2011. Publisher: Brazilian Chemical Society Abstract An alternative method for ethambutol (ETB) determination by UV spectrophotometry in pharmaceutical formulations using ETB complexation with Cu(II) was optimized […]
Antitubercular Activity of New Coumarins
Authors: Cardoso, S.H.; Barreto, M.B.; Lourenço, M.C.S.; Henriques, M.G.M.O.; Candea, A.L.P.; Kaiser, C.R.; De Souza, M.V.N. Source: Chemical Biology & Drug Design (Print), v. 77, p. 489-493, 2011. Publisher: John Wiley & Sons, Inc. Abstract The present article describes a series of 21 N ′-benzylidene-2-oxo-2H-chromene-3-carbohydrazides 4a–4v, which were synthesized and evaluated for their cell viabilities in […]
Simple Methodology for the Preparation of Amino Alcohols from Amino Acid Esters Using NaBH4-Methanol in THF
Authors: Gonçalves, R.S.B.; Pinheiro, A.C.; Da Silva, E.T.; Da Costa, J.C.S.; Kaiser, C.R.; De Souza, M.V.N. Source: Synthetic Communications, v. 41, p. 1276-1281, 2011. Publisher: Taylor & Francis Group Abstract Amino alcohols constitute a very useful and versatile class of organic compounds, with important applications in synthetic and medicinal chemistry. However, in most of the […]
Mefloquine derivatives: Crystal structures and anti-tubercular activities of diphenyl[((R,S)-2,8-bis(trifluoromethyl)quinolin-4-yl)-piperidin-2-yl-methanolato-O,N]boron and (±)-erythro-mefloquinium tetraphenylborate solvates
Authors: Wardell, J.L.; De Souza, M.V.N.; Wardell, S.M.S.V.; Lourenço, M.C.S. Source: Journal of Molecular Structure (Print), p. 67-74, 2011. Publisher: Elsevier Abstract Thermolysis of (R*,S*)-(2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)∼methyl}piperidin-1-ium) tetraphenylborate, (±)-erythro-mefloquinium tetraphenylborate, 3, in solution or neat, provides the oxazaborolidine derivative, diphenyl[(R*,S*)-(2,8-bis(trifluoromethyl)quinolin-4-yl)]piperidin-2-yl-methanolato-O,N]boron, 2. Crystal structures of solvates of 2 and 3 are reported. As shown by the 1H NMR […]
tert-Butyl -{(1)-1-[(2,4-dihydroxybenzylidene)hydrazinecarbonyl]-2-hydroxyethyl}carbamate ethanol monosolvate
Authors: Pinheiro, A.C.; De Souza, M.V.N.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 67, p. 581-582, 2011. Publisher: International Union of Crystallography Abstract The molecule of the title ethanol solvate, C15H21N3O6·C2H6O, adopts a curved shape; the conformation about the imine bond [N=N = 1.287 (3) Å] is E. The amide residues occupy positions […]
Synthesis and anti-mycobacterial activity of novel amino alcohol derivatives.
Authors: Cunico, W.; Gomes, C.R.B.; Ferreira, M.L.G.; Ferreira, T.G.; Cardinot, D.; De Souza, M.V.N.; Lourenço, M.C.S. Source: European Journal of Medicinal Chemistry, v. 46, p. 974-978, 2011. Publisher: Elsevier Abstract Thirteen new hydroxyethylamines have been synthesized from reactions of (2S,3S)Boc-phenylalanine epoxide, piperonylamine and arenesulfonyl chlorides in good yields. These compounds were evaluated as antibacterial agents […]
1,3-Dicyclohexyl-3-[(pyridin-2-yl)carbonyl]urea monohydrate from synchrotron radiation
Authors: Pinheiro, A.C.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 2676-2677, 2011. Publisher: International Union of Crystallography Abstract The title urea derivative crystallizes as a monohydrate, C19H27N3O2·H2O. The central C3N grouping is almost planar (r.m.s. deviation = 0.0092 Å), and the amide and pyridine groups are substantially […]
Pirazinamida: Um Fármaco Essencial no Tratamento da Tuberculose
Authors: Lima, C.H.S.; Ferreira, M.L.; De Souza, M.V.N. Source: Revista Virtual de Química, v. 3, p. 159-180, 2011. Publisher: Sociedade Brasileira de Química Abstract A pirazinamida (PZA) é um importante fármaco utilizado contra a tuberculose, que contribuiu para a redução do tempo de tratamento de 12 para 6 meses. A principal ação desse fármaco é a […]
Benzyl N-(1-{N'-[(E)-2,3-dihydroxybenzylidene]hydrazinecarbonyl}-2-hydroxyethyl)carbamate dihydrate
Authors: Wardell, S.M.. S.V.; Tiekink, E.R.T.; De Souza, M.V.N.; Pinheiro, A.C.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 67, p. 2155-2156, 2011. Publisher: International Union of Crystallography Abstract The organic molecule in the title dihydrate, C18H19N3O6·2H2O, adopts a twisted U-shape with the major twists evident about the chiral C atom [the C-N-C-C torsion angle is […]
tert-Butyl N-((1S)-2-hydroxy-1-{N'-[(E)-2-hydroxy-4-methoxybenzylidene]hydrazinecarbonyl}ethyl)carbamate
Authors: Wardell, J.L.; De Souza, M.V.N.; Pinheiro, A.C.; Tiekink, E.R.T.; Wardell, S.M.S.V. Source: Acta Crystallographica. Section E, v. E67, p. 1888-1889, 2011. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C16H23N3O6, is twisted about the chiral C atom with the dihedral angle formed between the amide residues being 76.9 (3)°. Overall, the […]
