tert-Butyl N-((1S)-2-hydroxy-1-{N'-[(1E)-4-methoxybenzylidene]hydrazinecarbonyl}ethyl)carbamate
Authors: Pinheiro, A.C.; De Souza, M.V.N.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 67, p. 1805-1806, 2011. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C16H23N3O5, is twisted about the chiral C atom, the dihedral angle formed between the amide residues being 79.6 (3)°. The conformation about the […]
Benzyl N-(1-{ N’-[(E)-2-chlorobenzylidene]hydrazinecarbonyl}-2-hydroxyethyl)carbamate
Authors: De Souza, M.V.N.; Pinheiro, A.C.; Tiekink, E.R.T.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 67, p. 1868-1869, 2011. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C18H18ClN3O4, is twisted about the chiral C atom with the dihedral angle between the two amide residues being 87.8 (5)°, but, overall, […]
Benzyl N-(2-hydroxy-1-{ N’-[(1E)-2-hydroxybenzylidene]hydrazinecarbonyl}ethyl)carbamate
Authors: Tiekink, E.R.T.; De Souza, M.V.N.; Pinheiro, A.C.; Wardell, S.M.S.V.; Wardell, J.L. Source: Acta Crystallographica. Section E, v. 67, p. 1866-1867, 2011. Publisher: International Union of Crystallography Abstract The molecule of the title compound, C18H19N3O5, adopts a curved arrangement with the terminal benzene rings lying to the same side. The hydroxylbenzene ring is close to […]
N’-[(E)-2-Methoxybenzylidene]pyrazine-2-carbohydrazide
Authors: De Souza, M.V.N.; Lima, C.H.S.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 1714-1715, 2011. Publisher: International Union of Crystallography Abstract In the title compound, C13H12N4O2, all the non-H atoms lie on a crystallographic mirror plane and an intramolecular N-HN hydrogen bond generates an S(5) ring; the conformation […]
Amodiaquine analogs. Synthesis and anti-leishmanial activity
Authors: Coimbra, E.S.; Silva, A.D.; Dias, R.M.P.; Corrales, R.C.N.R.; Bispo, M.L.F.; Kaiser, C.R.; De Souza, M.V.N. Source: Mediterranean Journal of Chemistry, v. 3, p. 106-113, 2011. Publisher: Astucia Group Abstract In this work, we report the synthesis and antileishmanial evaluation of 13 amodiaquine (AQ) derivatives (4-aminoquinoline-aryl and 4-quinolinylhydrazones series). The compounds were tested against four […]
Synthesis and Antitumoral Evaluation of 7-chloro-4-quinolinylhydrazones Derivatives.
Authors: Montenegro, R.C.; Lotufo, L.V.; Moraes, M.O.; Pessoa, C.O.; Rodrigues, F.A.R.; Bispo, M.L.F.; Cardoso, L.N.F.; Kaiser, C.R.; De Souza, M.V.N. Source: Medicinal Chemistry (Hilversum), v. 7, p. 599-604, 2011. Publisher: Bentham Science Abstract A series of twenty-one 7-chloro-4-quinolinylhydrazones derivatives (3a-u) have been synthesized and evaluated for their cytotoxic potential against three cancer cell lines using […]
Synthesis and Antitubercular Activity of New L-serinyl Hydrazone Derivatives.
Authors: Pinheiro, A.C.; Kaiser, C.R.; Nogueira, T.C.M.; Carvalho, S.A.; Da Silva, E.F.; Feitosa, L.O.; Henriques, M.G.M.O.; Candea, A.L.P.; Lourenço, M.C.S.; De Souza, M.V.N. Source: Medicinal Chemistry (Hilversum), v. 7, p. 611-623, 2011. Publisher: Bentham Science Abstract A series of 32 L-serinyl hydrazone derivatives have been synthesized and evaluated for their in vitro antibacterial activity against […]
(R*,S*)-(±)-1-(2-[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methylpiperidin-1-yl)ethanone methanol monosolvate.
Authors: Gonçalves, R.S.B.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 2714-2715, 2011. Publisher: International Union of Crystallography Abstract The title mefloquine derivative has been crystallized as its 1:1 methanol solvate, C19H18F6N2O2·CH3OH. Each of the methinehydroxyl residue [the C-C-C-O torsion angle is -16.35 (17) °] and the […]
2-{1-[2,8-Bis(trifluoromethyl)quinolin-4-yl]-3,5,6,7,8,8a-hexahydro-1 -1,3-oxazolo[3,4- ]pyridin-3-yl}phenol
Authors: Gonçalves, R.S.B.; Kaiser, C.R.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 1656-1657, 2011. Publisher: International Union of Crystallography Abstract In the title mefloquine-oxazolidine derivative, C24H20F6N2O2, the oxazoline ring adopts an envelope conformation (the flap atom is N) and the piperidine ring has a chair […]
Benzyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
Authors: De Souza, M.V.N.; Gonçalves, R.S.B.; .; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. o3313-o3314, 2011. Publisher: International Union of Crystallography Abstract The title molecule, C22H24F6N2O3, adopts a folded conformation whereby the carboxylate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline […]
tert-Butyl 2-{[2,8-bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidine-1-carboxylate
Authors: Gonçalves, R.S.B.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 3315-3316, 2011. Publisher: International Union of Crystallography Abstract The title molecule, C22H24F6N2O3, adopts a folded conformation whereby the carboxylate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline planes […]
Synthesis and Antimycobacterial Evaluation of N'-(E)-heteroaromaticpyrazine-2-carbohydrazide Derivatives
Authors: Lima, C.H.S.; Henriques, M.G.M.O.; Candea, A.L.P.; Lourenço, M.C.S.; Bezerra, F.A.F.M.; Kaiser, C.R.; De Souza, M.V.N. Source: Medicinal Chemistry (Hilversum), v. 7, p. 245-249, 2011 Publisher: Bentham Science Abstract A series of nine N’-(E)-heteroaromatic-pyrazine-2-carbohydrazide derivatives (5a-f and 6a-c) have been synthesized and evaluated against M. tuberculosis ATCC 27294 using the micro plate Alamar Blue assay (MABA), […]
