[:pb]Authors: Silveira, L. S.; De Souza, M. V. N.; Kaiser, C. R.; Wardell, J. L.; Wardell, S. M. S. V.
Source: Letters in Drug Design & Discovery, v. 15, p. 113-117, 2018
Publisher: Bentham Science
Background: In this study, we reported the in vitro cytotoxicity activities of a series of N-(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives against four human cancer cell lines.
Methods: Good activities were obtained for compounds having aryl groups = 2-hydroxyphenyl, pyridinyl, 5-nitrofuran-2-yl and 5-nitrothiophen-2-yl.
Results and Conclusion: The results indicate that this group of compounds is a good starting point for the potential discovery of new prototypes against cancer.
Keywords: cancer, cytotoxicity activity, quinoline derivatives, drugs, in vitro, cell lines
Document Type: Research Article
Publication date: Janeiro de 2018