Tagging drugs with heavy hydrogen made as easy as flicking a light switch
Photoredox reaction simplifies metabolism studies by swapping hydrogen for deuterium or tritium Tracking isotope-labelled drugs as they pass through the body might become as easy as switching on a light thanks to a photocatalytic reaction that attaches heavy hydrogen tags to molecules. Almost every pharmaceutical compound contains hydrogen atoms. Swapping some of these for their heavier […]
Easily synthesized compound found to be useful for removing fluoride and metal ions from drinking water
A pair of researchers at the Indian Institute of Science Education and Research Kolkata has found that an easily synthesized compound can be used to remove fluoride and metal ions from drinking water. In their paper published in the journal ACS Omega, Tanmay Das and Debasish Haldar describe how the compound was synthesized and how well […]
The chemistry behind cannabinoids explains how CBDs are saving lives (A complex subject)
Scientists are finally beginning to uncover some of the chemical mechanisms underlying the powerful medical benefits of marijuana and its cannabinoid compounds. The breakthrough came with the discovery of the body’s endocannabinoid system, a biological system based around signaling molecules highly similar to many of the phytocannabinoid (plant-based cannabinoid) compounds found in marijuana (cannabis). Cannabinoid receptors are […]
A semi-synthetic organism that stores and retrieves increased genetic information
1, and the most general route to this goal is the creation of semi-synthetic organisms whose DNA harbours two additional letters that form a third, unnatural base pair. Previous efforts to generate such semi-synthetic organisms2 culminated in the creation of a strain of Escherichia colithat, by virtue of a nucleoside triphosphate transporter from Phaeodactylum tricornutum, imports the requisite […]
In the deep ocean, these bacteria play a key role in trapping carbo
The organisms oxidize the nitrogen compound nitrite to “fix” inorganic carbon dioxide A mysterious group of microbes may be controlling the fate of carbon in the dark depths of the world’s oceans. Nitrospinae bacteria, which use the nitrogen compound nitrite to “fix” inorganic carbon dioxide into sugars and other compounds for food and reproduction, are responsible […]
Carbon can exceed four-bond limit – Chemists confirm links to six other atoms in unusual molecule
Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure-Activity Relationship (HQSAR) Modeling of Amino-Imino Tautomers
[:pb]Authors: Bispo, M.L.; Lima, C.H.S.; Cardoso, L.N.F.; Candea, A.; Bezerra, F.A.F.M.; Lourenço, M.C.; Henriques, M.; Alencastro, R.; Kaiser, C.R.; De Souza, M.V.N.; Albuqueurque, M. Source: PHARMACEUTICALS, v. 10, p. 52-68, 2017. Publisher: MDPI AG (Basel, Switzerland) Abstract In an ongoing research program for the development of new anti-tuberculosis drugs, we synthesized three series (A, B, […]
N-acylhydrazones containing thiophene nucleus: a new anticancer class
Authors: Cardoso, L.N.F.; Nogueira, T.C.M.; Rodrigues, F.A.R.; Oliveira, A.C.A.; Luciano, M.C.S.; Pessoa, C.O.; De Souza, M.V.N. Source: Medicinal Chemistry Research, v. 26, p. 1605-1608, 2017. Publisher: Springer International Publishing AG Abstract In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for […]
Synthesis and Evaluation of Anti-Tuberculosis and Anti-Cancer Activities of Hydrazones and N-Acylhydrazones by Using Sonochemistry, A New General Procedure
Authors: Pinto, L.S.; De Souza, M.V.N.; Kaiser, C.R. Source: Letters in Drug Design & Discovery, v. 14, p. 678-685, 2017. Publisher: Bentham Science Publishers Abstract Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report a new general and […]
Sonochemistry as a General Procedure for the Synthesis of Coumarins, Including Multigram Synthesis
Authors: Pinto, L.S.; De Souza. M.V.N. Source: Synthesis-Stuttgart, v. 49, p. 2677-2682, 2017. Publisher: Georg Thieme Verlag Stuttgart · New York Abstract This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was […]
Physicists Precisely Measure Proton’s Magnetic Moment
In a paper published in the journal Science, a team of physicists from Japan and Germany reports the most precise measurement ever made of the magnetic moment of the proton, allowing a fundamental comparison between matter and antimatter. The new result improves by a factor 11 the precision of the previous measurement, and is consistent […]
How bacteria survive in oxygen-poor environments
Biologists have revealed a mechanism by which bacterial cells in crowded, oxygen-deprived environments access oxygen for energy production, ensuring survival of the cell. The finding could explain how some bacteria, such as Pseudomonas aeruginosa (P. aeruginosa), are able to thrive in oxygen-poor environments like biofilms and resist antibiotics. P. aeruginosa biofilm infections are a leading […]
