Synthesis and Biological Evaluation of Novel 1,3-Benzoxathiol-2-one Sulfonamides against Toxic Activities of the Venom of Bothrops jararaca and Bothrops jararacussu Snakes
Authors: Chazin, E. ; Martins, L.; De Souza, M. V.; Gomes, C. R.; Da Silva, A. C.; Branco, M.; Sanchez, E.; Fuly, A.; Vasconcelos, T. Source: Journal of the Brazilian Chemical Society, v. 33, p. 2-12, 2022 Publisher: SciELO Abstract This work describes the synthesis of new 1,3-benzoxathiol-2-one sulfonamides and evaluation of ntheir ability to […]
[:pb]Experimental and computational evidence for stabilising parallel, offset π[C([double bond, length as m-dash]O)N(H)N[double bond, length as m-dash]C]⋯π(phenyl) interactions in acetohydrazide derivatives[:]
[:pb]Authors: Tan, S. L. ; Cardoso, L. N. F. ; De Souza, M. V. N. ; Wardell, S. M. S. V. ; Wardell, J. L. ; Tiekink, E. R. T. Source: CrystEngComm, v. 24, p. 962-974, 2022 Publisher: Royal Society of Chemistry Abstract Parallel, offset π[C(O)N(H)NC]⋯π(phenyl) interactions are observed in the crystal of (2-thienyl)CH2CON(H)–NC(H)Ph, along […]
[:pb]Camphor nitroimine: a key building block in unusual transformations and its applications in the synthesis of bioactive compounds[:]
[:pb] Authors: Silva, E.T.; Santos, L. S.; Andrade, G. F.; Rosa, E. J. R.; De Souza, M. V. N. Source: Molecular Diversity, v. 26, p. 3463-3483, 2022 Publisher: Springer Abstract The development of new drugs requires a lot of time and high financial investments. It involves a research network in which there is the participation […]
[:pb]New FDA oncology small molecule drugs approvals in 2020: Mechanism of action and clinical applications[:]
[:pb]Authors: Nogueira, T. C. M. ; De Souza, M. V. N. Source: Bioorganic & Medicinal Chemistry, v. 46, p. 116340, 2021. Publisher: ScienceDirect Abstract In 2020, fifty-three new drugs, including forty small-molecules (thirty-six new chemical entities and four new diagnostic agents) and thirteen biologic drugs were approved by the U.S. Food and Drug Administration (FDA). […]
[:pb]Green Synthesis of Five- and Six-membered N-heterocycles by Ultrasonic Irradiation in Aqueous Media [:]
[:pb]Authors: Nogueira, T. C. M.; De Souza, M. V. N. Source: Current Green Chemistry, v. 8, p. 99-126, 2021 Publisher: Bentham Science Publishers Abstract Five- and six-membered N-heterocyclic compounds play an important role in medicinal chemistry and the development of new drugs. There is a constant demand for the development of novel biologically potent compounds, […]
[:pb]Application of nitriles on the synthesis of 1,3-oxazoles, 2-oxazolines, and oxadiazoles: An update from 2014 to 2021[:]
[:pb]Authors: Facchinetti, V. ; Gomes, C. R. B. ; De Souza, M. V. N. Source: Tetrahedron, v. 102, p. 132544, 2021 Publisher: ScienceDirect Abstract The importance of 5-membered azaheterocycles is well established, especially in the medicinal chemistry field, as these nuclei are present in many marketed top-selling drugs, but also other areas such as catalysis, […]
[:pb]Simple and Efficient Eco-Friendly Multigram Procedure for Preparation of Piperazine Hydrochloride, an Important Building Block in Medicinal Chemistry[:]
[:pb]Authors: Costa, C.F. ; De Souza, M. V. N. ; Facchinetti, V. ; Gomes, C. R. B. Source: General Chemistry, v. 7, p. 210004, 2021 Publisher: General Chemistry Abstract This work describes the synthesis of piperazine hydrochloride in multigram scale and high yields with promising industrial applications. This methodology is simple, fast, safe, low cost, […]
[:pb]Synthesis of acrylic acid derivatives: a fast, multigram scale methodology via ultrasound irradiation[:]
[:pb]Authors: Costa, G. O.; Facchinetti, V. ; Bezzera, M. S. ; Gomes, C.R.B ; De Souza, M. V. N. Source: Brazilian Journal of Development, v. 7, p. 48138-48146, 2021 Publisher: Brazilian Journal of Development Abstract Acrylic acid derivatives are important chemicals found in cosmetics, coatings, adhesives, and others. Moreover, these substances are widely used in […]
[:pb]Antibacterial activity of new substituted 4-N-alkylated-2-trifluoromethyl-quinoline analogues against sensitive and resistant Mycobacterium tuberculosis strains[:]
[:pb]Authors: Da Silva, E. T. ; De Andrade, G. F. ; Araújo, A. S. ; Lourenço, M. C. S. ; De Souza, M. V. N. Source: European Journal of Pharmaceutical Sciences, v. 157, p. 105596, 2021. Publisher: ScienceDirect Abstract Objectives: The emergence of resistant strain has aggravated the tuberculosis situation in the world, running out […]
[:pb]Mefloquine synergism with anti-tuberculosis drugs and correlation to membrane effects: Biologic, spectroscopic and molecular dynamics simulations studies[:]
[:pb]Authors: Dos Santos, M. C. ; Scaini, J. L. R. ; Lopes, M. V. C. ; Rodrigues, B. G. ; Silva, N. O. ; Borges, C. R. L. ; Dos Santos, S. C. ; Dos Santos Machado, K. ; Werhli, A. V. ; Da Silva, P. E. A. ; Lourenço, M. C.S. ; Da Silva, […]
[:pb]Crystal structure, Hirshfeld surface analysis and PIXEL calculations of the three isomeric (E)-2-((pyridinylmethylidene)hydrazinyl)benzo[d]thiazoles: Occurrence of stacking interactions[:]
[:pb]Authors: Gomes, L. R. ; Low, J. N. ; Pinheiro, A. C. ; D Souza, M. V.N. ; Wardell, J. L. Source: Journal of Molecular Structure, v. 1230, p. 129907, 2021 Publisher: ScienceDirect Abstract Detailed structural analyses, utilizing crystal structure determinations, Hirshfeld surface analysis and PIXEL calculations have been carried out on the three isomeric (E)-2-((pyridin-X-ylmethylidene)hydrazinyl) benzo[d]thiazoles: […]
[:pb]Pharmacological profiling of JME-173, a novel mexiletine derivative combining dual anti-inflammatory/anti-spasmodic functions and limited action in Na+ channels[:]
[:pb]Authors: Pinto, D. P.; Coutinho, D. S.; De Carvalho, K. I. M.; Ferrero, M. R.; Da Silva, L. V.; Silveira, G. P. E.; Da Silva, D. M.; Araújo, J. F. G.; Silva, A. C. A.; Pereira, H. M.; Da Fonseca, L. B.; Faria, R. X.; De Souza, M. V. N.; Da Silva, E. T.; Santos-Filho, […]
