Fuzeon, o primeiro medicamento de uma nova classe anti-HIV denominada inibidores de fusão
Authors: De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 86, n.3, p. 112-116, 2005. Publisher: Associação Brasileira de Farmacêuticos Abstract A sindrome da imunodeficiêÍncia adquirida (SIDA) é uma das mais temidas doenças no mundo. Uma promissora·área de pesquisa é baseada no estudo e obtenção de fármacos capazes de prevenir a entrada do vírus na […]
Rifampicina, um importante fármaco no combate à tuberculose
Authors: De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 86, n.3, p. 92-94, 2005. Publisher: Associação Brasileira de Farmacêuticos Abstract A tuberculose (TB) representa, nos dias atuais, um importante problema de sa ̇de pública mundial responsavel pela morte anual de 3 milhões de pessoas. Na luta contra a tuberculose, a rifampicina representa um importante […]
2-chloropyridine-3-carboxylic acid
Authors: De Souza, M.V.N.; Wardell, S.M.S.V.; Howie, R.A. Source: Acta Crystallographica. Section E, v. E61, p. 1347-1349, 2005. Publisher: International Union of Crystallography Abstract The molecules of the title compound, C6H4ClNO2, are almost completely planar. Hydrogen bonds of the form O-HN interconnect the molecules to form infinite chains, which are also planar and which are […]
Supramolecular structures of three isomeric 2-chloro-N-(nitrophenyl)nicotinamides
Authors: De Souza, M.V.N.; Vasconcelos, T.R.A.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C61, p. 204-208, 2005 Publisher: International Union of Crystallography Abstract Molecules of 2-chloro-N-(2-nitrophenyl)nicotinamide, C12H8ClN3O3, are linked by two C-HO hydrogen bonds into a chain of edge-fused (14) and (24) rings. In 2-chloro-N-(3-nitrophenyl)nicotinamide […]
New Fluoroquinolones: A Class of Potent Antibiotics
Authors: De Souza, M.V.N. Source: Mini – Reviews in Medicinal Chemistry, v. 5, n.11, p. 1009-1018, 2005. Publisher: Bentham Science Abstract The discovery of antibiotics opened a new era in the treatment against several pathogenic microorganisms that can disable or kill humans. The appearance of the fluoroquinolones (based on nalidixic acid, 4-quinolone-3-carboxylates), in the early […]
Furanones, Recent synthetic methodologies and your application in synthesis of natural products.
Authors: De Souza, M.V.N. Source: Mini-Reviews in Organic Chemistry, v. 2, p. 139-145, 2005. Publisher: Bentham Science Abstract In recent years, furan-2(5H)-ones have attracted considerable attention as synthetic target. This subunit is present in a large number of natural products, which display a wide range of biological activities, and is present in a number of […]
ynthesis of 2,3-Dihydrofuro[3,2-c]pyridine-3,4-dicarboxylic Acid, a Conformationally Constrained Analogue of the Subtype Selective NMDA Receptor Agonist Homoquinolinic Acid
Authors: De Souza, M.V.N.; Yan, Z. ; Dodd, R. H. Source: Heterocycles, v. 64, p. 261, 2004. Publisher: The Japan Institute of Heterocyclic Chemistry Publications Abstract 4-Allyloxy- and 4-prop-2-ynyloxy-3-iodopicolinic acid derivatives, obtained by reaction of 4-chloro-2-iodopicolinanilides (11,14) with the sodium salts of allyl alcohol and propargyl alcohol, respectively, were subjected to tri-n-butyltin hydride/AIBN free radical cyclization […]
A simple reduction of methyl aromatic esters to alcohols using sodium borohydride–methanol system
Authors: De Souza, M.V.N.; Mello, S.C.P.; Boechat, N.; Mendonça, J.S.; Costa, J. Source: Tetrahedron Letters, v. 45, p. 6021-6022, 2004. Publisher: Elsevier Abstract Several aromatic esters were reduced to the corresponding alcohol by using sodium borohydride–methanol system. The reduction was completed within 2.0–4.0 h after refluxing in THF. The alcohol products were isolated after aqueous workup […]
(+)-Discodermolide: a Marine Natural Product Against Cancer
Authors: De Souza, M.V.N. Source: The Scientific World Journal, v. 4, p. 415-436, 2004. Publisher: Hindawi Publishing Corporation Abstract (+)-Discodermolide was isolated in 1990 by Gunasekera et al. from the deep-water Caribbean sponge Discodermia dissoluta. It attacks cancer cells in a similar way to the successful cancer drug Taxol® that has become the best-selling anticancer […]
Entry Inhibitors – A New Class of Aids Drugs
Authors: De Souza, M.V.N. Source: Letters in Drug Design & Discovery, v. 1, p. 184-193, 2004. Publisher: Bentham Science Abstract The human immunodeficiency virus (HIV), a retrovirus, is known to cause the acquired immunodeficiency syndrome (AIDS) as the HIV infection develops. Efforts on searching new anti-HIV agents to provide effective treatment of HIV infection / AIDS […]
Ciprofloxacina, uma importante arma no combate ao antraz
Authors: De Souza, M.V.N.; Silva, A.D.; Almeida, M.V.; Couri, M.R.C. Source: Revista Brasileira de Farmácia, v. 85, n.1, p. 13-18, 2004. Publisher: Associação Brasileria de Farmacêuticos Abstract A ciprofloxacina é um potente antibiótico da classe fluorquinolonas que possui um amplo espectro de atividade contra vários microoganismos patogênicos que podem incapacitar ou matar seres humanos e animais. […]
Utilização do TEMPO (N-oxil-2,2,6,6-tetrametilpiperidina) na oxidação de álcoois primários e secundários
Authors: De Souza, M.V.N. Source: Química Nova, v. 27, p. 287-292, 2004. Publisher: Sociedade Brasileira de Química Abstract The oxidation of alcohols to obtain ketones, aldehydes or carboxylic acids is a fundamental transformation in organic synthesis and many reagents are known for these conversions. However, there is still a demand for mild and selective reagents […]
