Pyrrole-2-carbaldehyde isonicotinoylhydrazone monohydrate redetermined at 120K
Authors: De Souza, M.V.N.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C62, p. 047-049, 2006. Publisher: International Union of Crystallography Abstract In the title compound, C11H10N4O·H2O, there are five independent hydrogen bonds, of O-HO, O-HN and N-HO types, which link the components into complex sheets parallel to (001). […]
Fármacos no combate à tuberculose: passado, presente e futuro
Authors: De Souza, M.V.N.; Vasconcelos, T.R.A. Source: Química Nova (Impresso), v. 28, n.4, p. 678-682, 2005. Publisher: Sociedade Brasileira de Química Abstract Approximately every minute, somewhere in the world four people die from tuberculosis (TB), an infection of Mycobacterium tuberculosis with about 3 million deaths per year. In spite of these problems, unfortunaly, it is […]
Plants and Fungal Products with activity against Tuberculosis
Authors: De Souza, M.V.N. Source: The Scientific World Journal, v. 5, p. 609-628, 2005. Publisher: Hindawi Publishing Corporation Abstract Tuberculosis (TB) is becoming an ever more serious worldwide problem. This contagious disease kills four people every minute somewhere in the world and accounts for more than 2 million deaths per year. Due to the rapid […]
Evaluating of the Effect of the Antimonium Pentachloride Feed Rate to Ensure Safe Conditions for the Synthesis of Meglumine Antimoniate
Authors: De Souza, M.V.N.; Barreto Jr.; A.G.; Estevão, L.R.M.; Biscaia Jr., E.C.; Carvalho, S.A.; Duarte, S.L.; Mendonça, J.S.; Costa, J.C.S.; Silva, J.F.C. Source: Industrial & Engineering Chemistry Research, v. 44, p. 6578-6582, 2005. Publisher: American Chemical Society Abstract Pentavalent antimony derivatives, among them meglumine antimoniate, are widely used in antileishmanial therapy. The production of meglumine […]
Simple Reduction of Heteroaromatic Esters to Alcohols Using a Sodium Borohydrideâ Methanol System
Authors: De Souza, M.V.N.; Boechat, N. ; Mello, S.C.P.; Costa, J.C.S. ; Mendonça, J.S. ; Fernandes, E.L. ; Pais, K.C. Source: Synthetic Communications, v. 35, p. 3187-3190, 2005. Publisher: Taylor & Francis Group Abstract Some heteroaromatic esters were reduced to the corresponding alcohols by using a sodium borohydride–methanol system. The reduction was completed within 0.15–2.0 h in refluxing THF. […]
Synthesis and biological activity of natural thiazoles: An important class of heterocyclic compounds
Authors: De Souza, M.V.N. Source: Journal of Sulfur Chemistry (Print), v. 26, n.4, p. 429-449, 2005. Publisher: Francis & Taylor Group Abstract The class of heterocyclic compounds known as thiazole is found in many natural and synthetic products with a wide range of pharmacological activities, such as antiviral, anticancer, antibacterial, antifungal, anticonvulsant, antiparkinsonian and anti-inflammatory […]
Métodos de obtenção e aplicações sintéticas de tiazolas, uma importante classe de compostos heterocíclicos
Authors: De Souza, M.V.N.; Mendonça, J.S.; Ferreira, S.B.; Costa, M.; Rebello, F.R. Source: Química Nova, v. 28, p. 77-84, 2005. Publisher: Sociedade Brasileira de Química Abstract Thiazoles comprise an important class of heterocyclic compounds present in many potent biologically active molecules. This heterocyclic ring also shows various applications in organic synthesis to obtain new compounds. […]
Fármacos inibidores de fusão: uma nova estratégia no combate à replicação do vírus VIH
Authors: De Souza, M.V.N. Source: Acta Farmacéutica Bonaerense, v. 24, n.2, p. 291-9, 2005 Publisher: Colégio de Farmaceuticos de la provincia de Buenos Aires Abstract Atualmente, o tratamento no combate ao vírus HIV é baseado na inibição das enzimas necessárias à sua replicação nas células infectadas. Comumente, uma combinação de medicamentos, capazes de inibir as […]
Four nitrobenzaldehyde isonicotinoylhydrazones at 120K: four different supramolecular strucutures in two and three dimensions
Authors: De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Low, J.N. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C61, p. 683-689, 2005 Publisher: International Union of Crystallography Abstract The molecules of 2-nitrobenzaldehyde isonicotinoylhydrazone, C13H10N4O3, (I), are linked into a three-dimensional framework by a combination of one N-HN and three C-HO hydrogen bonds. In the […]
8-Methyl-5–oxo-5,6-dihydrodipyrido[1,2-a:3',2'-e]-pyrimidin-11-ium chloride trihydrate 120k
Authors: De Souza, M.V.N.; Vasconcelos, T.R.A.; Wardell, S.M.S.V.; Wardell, J.L.; Ferreira, M.L.; Howie, R.A. Source: Acta Crystallographica Section C, v. E61, p. 3579-3581, 2005. Publisher: International Union of Crystallography Abstract The difluorinated ring in 2,4-difluorobenzaldehyde isonicotinoylhydrazone, C13H9F2N3O, (I), is disordered over two sets of sites with unequal occupancy. The molecules of (I) are linked by a combination of […]
[pi]-Stacked hydrogen-bonded chains of rings in 2,4-difluorobenzaldehyde isonicotinoylhydrazone and hydrogen-bonded sheets in 2,3-dichlorobenzaldehyde isonicotinoylhydrazone
Authors: De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Ferreira, M.L.; Vasconcelos, T.R.A.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. 61, p. 617-620, 2005. Publisher: International Union of Crystallography Abstract The difluorinated ring in 2,4-difluorobenzaldehyde isonicotinoylhydrazone, C13H9F2N3O, (I), is disordered over two sets of sites with unequal occupancy. The molecules […]
Synthesis and Anti-Mycobacterial Activity of N'-[(E)-(Disubstituted- Phenyl)Methylidene]Isonicotino-Hydrazide Derivatives
Authors: De Souza, M.V.N.; Vasconcelos, T.R.A.; Mello, S.C.P.; Wardell, S.M.S.V.; Peralta, M.A.; Ferreira, B.; Henriques, M.G.M.O.; Neves Jr., I.; Lourenço, M.C.S. Source: Letters in Drug Design & Discovery, v. 2, p. 563-566, 2005. Publisher: Bentham Science Abstract A series of eight N-[(E)-(disubstituted-phenyl)methylidene]isonicotino-hydrazide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium […]
