Novos Produtos Naturais Capazes de Atuar na Estabilização de Microtubos: um Importante Alvo no Combate ao Câncer
Authors: De Souza, M.V.N. Source: Química Nova, v. 27, p. 308-312, 2004 Publisher: Sociedade Brasileira de Química Abstract Microtubules are involved in many aspects of cellular biology and represent an important target of anticancer chemotherapeutics. In the past five years, novel natural products such as epothilones, discodermolide, sarcodictyin, eleutherobin, and laulimalide, all of which have […]
Métodos de Preparação e Atividade Biológica do Ácido Quinolínico
Authors: De Souza, M.V.N.; Almeida, M.V.; Hyaric, M.L.; Amarante, G.W.; Cardoso, S.H. Source: Química Nova, v. 26, n.5, p. 694-698, 2003. Publisher: Sociedade Brasileira de Química Abstract In 1981 2,3-pyridine dicarboxylic acid (quinolinic acid) was discovery to be a selective agonist for the N-methyl -D-aspartic acid (NMDA) receptor. As a consequence it possesses neurotoxic activity […]
Synthesis of 2-Deoxystreptamine Derivatives
Authors: De Souza, M.V.N.; Almeida, M.V.; Hyaric, M.L.; Silva, E.T.; Almeida, A.S.M.; Santiago, R.M. Source: Journal of Carbohydrate Chemistry, v. 22, n.7 & 8, p. 733-742, 2003. Publisher: Taylor & Francis Group Abstract A protected C‐3 epi‐2‐deoxystreptamine was synthesized starting with the intermediate 2‐l‐1,3/2,4,5‐1‐acetamido‐2,3,4‐tri‐O‐benzyl‐2,3,4,5‐cyclohexanetetrol 8, derived from d‐glucose. Keywords: Streptamine, Aminoglycoside, Antibiotic Document Type: Research […]
Drogas anti-VIH: passado, presente e futuras perspectivas
Authors: De Souza, M.V.N.; Almeida, M.V.; Source: Química Nova, v. 26, n.3, p. 366-373, 2003. Publisher: Sociedade Brasileira de Química Abstract Currently available anti-HIV drugs can be classified into three categories: nucleoside analogue reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs). In addition to the reverse transcriptase (RT) and protease […]
Cascata dos Fosfoinositídeos
Authors: De Souza, M.V.N.; Almeida, M.V.; Silva, A.D.; Benicio, A.A. Source: Química Nova, v. 26, n.1, p. 105-111, 2003. Publisher: Sociedade Brasileira de Química Abstract Inositol is a polyalcohol required for the proper formation of cell membranes. In the body, its plays an important role in the transmission of nerve impulses, its also helps in […]
Biological Activity and Synthetic Metodologies for the Preparation of Fluorquinolones, A Class of Potent Antibacterial Agents
Authors: De Souza, M.V.N.; Almeida, M.V.; Couri, M.R.C.; Silva, A.D. Source: Current Medicinal Chemistry, v. 10, n.1, p. 21-40, 2003. Publisher: Bentham Science Abstract In this present review we report different synthetic methodologies for the preparation of fluoroquinolones and their biological properties. The appearance of the fluoroquinolones, a new class of antibacterial agents (based on […]
Synthesis of Platinum Complexes from N-Benzyl-2-Aminoethanethiol Derivatives
Authors: De Souza, M.V.N.; Almeida, M.V.; Oliveira, L.L.C. Source: The Scientific World Journal, v. 3, p. 348-353, 2003. Publisher: Hindawi Publishing Corporation Abstract Twelve new platinum(II) complexes, analogs of cisplatin, containing a 2-aminoethanethiol N-substituted by several benzyl groups have been prepared and characterized in good yields. The ligands were obtained by reaction between 2-aminoethanethiol hydrochloride […]
Síntese e Reatividade dos Azaindois: Aplicação a Síntese de Moléculas de Interesse Biológico
Authors: De Souza, M.V.N.; Almeida, M.V.; Hyaric, M.L. Source: Química Nova, v. 25, n.6B, p. 1165-1171, 2002 Publisher: Sociedade Brasileira de Química Abstract Synthetic methods used for the preparation of azaindoles are described in this article. Applications in the preparation of bioactive molecules are given: synthesis of substituted 6-azaindoles as benzodiazepines receptor ligands, substituted 7-azaindoles […]
Síntese de derivados iodados do L-quebrachitol
Authors: Da Silva, A.D.; Almeida, M.V.; De Souza, M.V.N.; Porto, R.S.; Siqueira, F.A. Source: Principia (Rio de Janeiro), Brasil, v. 6, p. 55-57, 2002. Publisher: Pró-Reitoria de Pesquisa da UFJF Abstract None Keywords: None Document Type: Research Article DOI: None Publication date: 1 de Janeiro de 2002
Ortometalação de Piridinas
Authors: De Souza, M.V.N.; Almeida, M.V. Source: Química Nova, v. 25, n.1, p. 89-98, 2002 Publisher: Sociedade Brasileira de Química Abstract In this paper we describe a powerful methodology for the regiospecific construction of polysubstituted aromatic and heteroaromatic compounds. The DoM reaction (direct ortho-metalation) comprises the deprotonation in position ortho of a aromatic or heteroaromatic […]
Synthetic Applications of 3-Amino-5-Piperidein-2-ones: Synthesis of Methionine-Derived Peptidomimetics
Authors: De Souza, M.V.N.; Rubiralta, M.; Diez, A.; Dodd, R.H.; Rio, X.; Estiarte, A. Source: Tetrahedron (Oxford), EUA, v. 55, p. 10173-10186, 1999. Publisher: Elsevier Abstract A method is described for the efficient preparation of 3-amino-Δ5-piperidein-2-ones3. A synthetic application of enamides 3 has been achieved by methylthiolation on the C5 position to obtain the target […]
ortho-Directed Lithiation Studies of 4-Chloropicolinanilide : Introduction of Functional Groups at C-3 and Their Elaboration to Chain Extended Derivatives via Carbon-Carbon Bond Formation
Authors: Dodd, R.H.; De Souza, M.V.N. Source: Heterocycles (Sendai), v. 47, p. 811, 1998. Publisher: The Japan Institute of Heterocyclic Chemistry Abstract An improved synthesis of 4-chloropicolinanilide (3) is presented. Treatment of 3 with lithium diisopropylamide (LDA) in THF, followed by addition of an electrophile (methyl iodide, iodine, carbon dioxide, trimethylstannyl chloride), gave exclusively the […]
