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Triterpenos como Inibidores de Fusão: Uma Nova Estratégia no Combate ao Vírus HIV.

Authors: Gonçalves, R.S.B.; Ferreira, M.L.; Peralta, M.A.; De Souza, M.V.N. Source: Revista Fitos (ALANAC), v. 2, p. 74-81, 2006. Publisher: FIOCRUZ Abstract A Síndrome da Imunodeficiência Adquirida (SIDA) é uma das doenças mais assustadoras no mundo. Inúmeros esforços têm sido realizados na descoberta de novos agentes terapêuticos, capazes de combater o VIH-1 (Vírus da Imunodeficiência […]

Tuberculose em gestantes: um importante problema de saúde pública mundial

Authors: De Souza, M.V.N. Source: Revista Brasileira de Farmácia, v. 87, p. 132-138, 2006. Publisher: Associação Brasileira de Farmacêuticos Abstract Tuberculose (TB) é uma doença infecto-contagiosa, transmitida pelo ar, cujo agente etiológico é o Mycobacterium tuberculosis que atualmente se tornou um problema de saúde pública mundial, afetando todas as idades. De acordo com as estatísticas, […]

Four substituted benzohydrazides: hydrogen-bonded structures in one, two and three dimensions

Authors: De Souza, M.V.N.; Low, J.N.; Wardell, Vasconcelos, T.A.; S.M.S.V.; Wardell, J.L.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C62, p. 618-624, 2006. Publisher: International Union of Crystallography Abstract The mol­ecules of 2,6-dichloro­benzohydrazide, C7H6Cl2N2O, are linked into simple chains by a single N-HO hydrogen bond, while in the isomeric compound 2,4-dichloro­benzo­hydrazide, […]

TEMPO(2,2,6,6-tetramethylpiperidine-N-oxyl) an Important Reagent in Alcohol Oxidation and its Application in Synthesis of Natural Products

Authors:  De Souza, M.V.N. Source: Mini-Reviews in Organic Chemistry, v. 3, n.2, p. 155-165, 2006. Publisher: Bentham Science Abstract The oxidation of alcohols is a fundamental transformation in organic synthesis and a large number of reagents have been developed for this purpose. In spite of the different methodologies, the modern organic synthesis still requires more […]

Fluoroquinolones: An Important Class of Antibiotics Against Tuberculosis

Authors: De Souza, M.V.N.; Vasconcelos, T.A.; Cardoso, S.H.; Almeida, M.V. Source: Current Medicinal Chemistry, v. 13, n.4, p. 455-463, 2006. Publisher: Bentham Science Abstract Tuberculosis (TB) is a global health problem due to the lack of new drugs in the market and also due to the advent of multidrug resistant strains (MDR). This disease affects around […]

Simple chains in methyl 3,5-dinitrobenzoate, isolated molecules in isopropyl 3,5-dinitrobenzoate and a three-dimensional framework containing double and sextuple helices in benzyl 3,5-dinitrobenzoate

Authors: De Souza, M.V.N.; Vasconcelos, T.A.; Wardell, S.M.S.V.; Wardell, J.L.; Low, J.N.; Glidewell, C. Source: Acta Crystallographica. Section C, Crystal Structure Communications, v. C62, p. 26-29, 2006. Publisher: International Union of Crystallography Abstract Mol­ecules of methyl 3,5-dinitro­benzoate, C8H6N2O6, are linked into C(7) chains by a single nearly linear C-HO hydrogen bond, but there are no direction-specific […]

Promising Drugs Against Tuberculosis

Authors: De Souza, M.V.N. Source: Recent Patent Reviews on Anti-Infective Drug Discovery, v. 1, n.1, p. 33-44, 2006. Publisher: Bentham Science Abstract Tuberculosis (TB) is an important public health problem worldwilde due to AIDS epidemic, the advent of multidrug resistant strains (MDR) and the lack of new drugs in the market. TB is responsible for […]

Stille Reaction: An Important tool in the synthesis of complex natural products

Authors: De Souza, M.V.N. Source: Current Organic Synthesis, v. 3, p. 313-326, 2006. Publisher: Bentham Science Abstract Nowadays, palladium-catalysed coupling reactions are one of the most efficient procedures for the construction of C-C bonds. In this context, a reaction that is known as Stille reaction, published in 1978 by J. K. Stille and D. Milstein, […]

Synthesis and In Vitro Anti-Tubercular Activity of a Series of N'-(Disubstitutedbenzoyl)Isoniazid Derivatives

Authors: De Souza, M.V.N.; Neves Jr., I.; Miranda, G.B.P.; Lourenço, M.C.S.; Vasconcelos, T.A.; Pais, K.C.; Wardell, J.L.; Wardell, S.M.S.V.; Alcântara Jr.; J.P. Source: Letters in Drug Design & Discovery, v. 3, p. 424-428, 2006. Publisher: Bentham Science Abstract A series of eight N-(disubstitutedbenzoyl)isoniazid derivatives have been synthesized and evaluated for their in vitro antibacterial activity […]

A Simple Reduction of ethyl, isopropyl and benzyl aromatic esters to Alcohols Using Borohydride – Methanol System

Authors: De Souza, M.V.N.; Mendonça, J.S.; Fernandes, E.L.; Pais, K.C.; Costa, J.C.S.; Vasconcelos, T.A. Source: ARKIVOC, v. 1, p. 128-133, 2006. Publisher: Arkat USA, Inc. Abstract Several aromatic ethyl, isopropyl and benzylesters were reduced to their corresponding alcohols in sodium borohydride-methanol system. The reductions were completed within 15-60 minutes in refluxing THF. The alcohol products […]