2-{[2,8-Bis(trifluoromethyl)quinolin-4-yl](hydroxy)methyl}piperidin-1-ium 3-amino-5-nitrobenzoate sesquihydrate
Authors: De Souza, M.V.N.; .; Wardell, J.L.; Wardell, S.M.S.V.; Ng, S.W.; Tiekink, E.R.T. Source: Acta Crystallographica. Section E, v. 67, p. 3019-3020, 2011. Publisher: International Union of Crystallography Abstract The asymmetric unit of the title salt solvate, C17H17F6N2O+·C7H5N2O4–·1.5H2O, comprises a piperidin-1-ium cation, a 3-amino-5-nitrobenzoate anion, and three fractionally occupied [i.e. 0.414 (3), 0.627 (6) and 0.459 (5)] disordered […]
Sodium Chlorite (NaClO2): an Important Reagent in Alcohol and Aldehyde Oxidation and its Application in Total Synthesis of Natural Products
Authors: De Souza, M.V.N.; Ferreira, M.L.; Cardoso, L.N.F. Source: Journal of Biologically Active Products from Nature, v. 1, p. 52-80, 2011. Publisher: Taylor & Francis Group Abstract The oxidation of alcohols is a fundamental transformation in organic synthesis and a large number of reagents have been developed for this purpose. In spite of the different […]
Produtos Naturais com atividade inibitória da Translocase I, uma promissora classe de compostos contra tuberculose
Authors: De Souza, M.V.N.; Facchinetti, V. ; Carvalho, D.C.; Gomes, C.R.B. Source: Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas, v. 9, p. 1-12, 2010. Publisher: Red de Revistas Científicas de América Latina y el Caribe, España y Portugal Abstract Atualmente, a tuberculose (TB), doença infecto-contagiosa cujo agente etiológico é o Mycobacterium tuberculosis é um […]
Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives
Authors: Gonçalves, R.S.B.; Kaiser, C.R.; Lourenço, M.C.S.; De Souza, M.V.N.; Wardell, J.L.; Wardell, S.M.S.V.; Da Silva, A.D. Source: European Journal of Medicinal Chemistry, p. 6095-6100, 2010 Publisher: Elsevier Abstract In this work, we report the synthesis and the antitubercular evaluation of 16 new mefloquine derivatives, formed from reactions between mefloquine and benzaldehydes, with the activity […]
Nitroimidazóis: uma promissora classe de substâncias para o tratamento da Tuberculose
Authors: Da Silva, M.M.; Silva, D.O.; Gomes, C.R.B.; De Souza, M.V.N. Source: Revista Virtual de Química, v. 2, p. 105-117, 2010 Publisher: Sociedade Brasileira de Química Abstract Tuberculosis (TB) is a contagious infectious disease caused by Mycobacterium tuberculosis. According to statistical dates each year, 9.27 million people worldwide develop active TB and almost 1.77 million […]
Antimycobacterial Profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone Derivatives
Authors: Carvalho, S.A.; Silva, E.F.; Lourenço, M.C.; De Souza, M.V.N.; Fraga, C.A.M. Source: Letters in Drug Design & Discovery, v. 7, p. 606-609, 2010 Publisher: Bentham Science Abstract In this work we report the tuberculostatic profile of a series of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone derivatives (1a-m). The evaluation of their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv was […]
Synthesis and Antitubercular Evaluation of New Bis-1,2,3-Triazoles Derived from D-Mannitol
Authors: Ferreira, M.L.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Vasconcelos, T.R.A.; Ferreira, V.; Lourenço, M. Source: Journal of Carbohydrate Chemistry, v. 29, p. 265-274, 2010 Publisher: Taylor & Francis Group Abstract Five new bis-1,2,3-triazole derivatives from D-mannitol, namely 2,3,4,5-tetra-O-acetyl-1,6-dideoxy-1,6-bis-(4-substituted-1H-1,2,3-triazol-1-yl)-D-mannitol (4), have been synthesized from 2,3,4,5-tetra-O-acetyl-1,6-diazido-1,6-dideoxy-D-mannitol (3) and alkynes, employing copper (I)-catalyzed azide-alkyne cycloaddition (CuAAC) methodology. […]
A importância do Núcleo quinolínico e seus derivados no desenvolvimento de fármacos
Authors: Pinheiro, A.C.; Ferreira, M.L.; De Souza, M.V.N. Source: Revista Fitos (ALANAC), v. 05, p. 53-63, 2010 Publisher: FIOCRUZ Abstract No campo da descoberta de fármacos, o núcleo quinolínico é uma importante classe de compostos heterocíclicos, visto que está presente em muitos produtos naturais e sintéticos, os quais possuem um amplo espectro de atividades biológicas. […]
Hydrated (pyrazinecarbonyl)hydrazones of hydroxy and methoxy substituted benzaldehydes
Authors: Howie, R.A.; Lima, C.H.S.; Kaiser, C.R.; De Souza, M.V.N.; Wardell, S.M.S.V. Source: Zeitschrift für Kristallographie, v. 225, p. 349-358, 2010 Publisher: De Gruyter Abstract The crystal structures of hydrates of five substituted benzaldehyde (pyrazinecarbonyl)hydrazone derivatives [N2C4H3CONHN=CHC6H5-nXn · m H2O: m = 1, n = 1, X = 3-HO; m = 1, n = 2, X2 […]
Structures of arylaldehyde 7-chloroquinoline-4-hydrazones:supramolecular arrangements derived from N H•••N, C H••• X ( X = N, O, or π) and π•••π interactions
Authors: Howie, R.A.; De Souza, M.V.N.; Ferreira, M.L.; Kaiser, C.R.; Wardell, J.L.; Wardell, S.M.S.V. Source: Zeitschrift für Kristallographie, v. 225, p. 440-447, 2010 Publisher: De Gruyter Abstract The molecules of the 7-chloroquinoline-4-hydrazones of the variously substituted benzaldehydes, 5, of general formula C16H11ClN3X with X = H, o-F, m-F or m-MeO corresponding to compounds (5: X = […]
Synthesis and Antitubercular Activity of Heteroaromatic Isonicotinoyl and 7-Chloro-4-Quinolinyl Hydrazone Derivatives
Authors: Ferreira, M.L.; Gonçalves, R.S.B.; Cardoso, L.N.F.; Kaiser, C.R.; Candea, A.L.P.; Henriques, M.G.M.O.; Lourenço, M.C.; Bezerra, F.A.F.M.; De Souza, M.V.N. Source: The Scientific World Journal, v. 10, p. 1347-1355, 2010 Publisher: Hindawi Publishing Corporation Abstract Two series of N’(E)-heteroaromatic-isonicotinohydrazide derivatives (3a-f and 4a-b) and 1-(7-chloroquinolin-4-yl)-2-[(heteroaromatic)methylene]hydrazone derivatives (5a-f and 6a-b) have been synthesized and evaluated for their […]
Simultaneous determination of first-line anti-tuberculosis drugs by capillary zone electrophoresis using direct UV detection
Authors: Faria, A.F.; De Souza, M.V.N.; Bruns, R.E.; De Oliveira, M.A.L.; Source: Talanta (Oxford), p. 333-339, 2010 Publisher: Elsevier Abstract An alternative methodology for simultaneous analysis of ethambutol, isoniazid, rifampicin and pyrazinamide in pharmaceutical formulations by capillary zone electrophoresis under UV direct detection with an analysis time of 8.0 min is proposed. Background running was based […]
