[:pb]Synthesis, biological activity, and mechanism of action of new 2-pyrimidinyl hydrazone and N-acylhydrazone derivatives, a potent and new classes of antileishmanial agentes[:]
[:pb]Authors: Coimbra, E. S.; De Souza, M. V. N.; Terror, M. S.; Pinheiro, A. C.; Granato, J. T. Source: European Journal of Medicinal Chemistry, v. 184, p. 111742-111742, 2019 Publisher: Science Direct Abstract In this work, we report the antileishmanial activity of 15 compounds based on 2-pyrimidinyl hydrazone and N-acylhydrazone derivatives, being 13 new compounds. All compounds were […]
[:pb]4H-1,3-Benzothiazin-4-one a promising class against MDR/XDR-TB[:]
[:pb]Authors: De Souza, M. V. N.; Nogueira, T. C. M. Source: Current Topics in Medicinal Chemistry, v. 19, p. 567-578, 2019 Publisher: Bentham Science Abstract Nowadays, tuberculosis (TB) is an important global public health problem, being responsible for millions of TB-related deaths worldwide. Due to the increased number of cases and resistance of Mycobacterium tuberculosis […]
[:pb]Synthesis and antibacterial activity of Mefloquine-based analogs against sensitive and resistant Mycobacterium tuberculosis strains[:]
[:pb]Authors: Araujo, A. S.; Moraes, A. M.; Lourenco, M. C. S. ; Pessoa, C. O. ; Da Silva, E. T.; De Souza, M. V. N. Source: Current Topics in Medicinal Chemistry, v. 19, p. 683-689, 2019 Publisher: Bentham Science Abstract Background and Introduction: Mefloquine, a drug used to prevent and treat malaria is described possessing activity against […]
[:pb]Different substituent effects on the supramolecular arrays in some (E)-halo- and nitro-benzaldehyde oximes: confirmation of attractive π(C=N)···π(phenyl) interactions[:]
[:pb]Authors: Gomes, L. R. ; Low, J. N. ; Van Mourik, T.; Früchtl, H.; De Souza, M. V. N. ; Da Costa, C. F. ; Wardell, J. L. Source: Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences, v. 74, p. 319-334, 2019 Publisher: De Gruyter Abstract The crystal structures and Hirshfeld surface analyses are reported […]
[:pb](1,3-Benzothiazol-2-yl)benzenesulfonohydrazide: crystal structure, Hirshfeld surface analysis and computational chemistry[:]
[:pb]Authors: Baddeley, T. C.; De Souza, M. V. N.; Wardell, J. L.; Jotani, M. M.; Tiekink, E. R. T. Source: Acta Crystallographica Section e, Crystallographic Communications, v. 75, p. 516-523, 2019 Publisher: Science Direct Abstract The asymmetric unit of the title compound, C13H11N3O2S2, comprises two independent molecules (A and B); the crystal structure was determined by employing synchrotron radiation. […]
[:pb]Crystal structures, Hirsfeld surface analysis and a computational study of four ethyl 2-oxo-2H-chromene-3-carboxylate derivatives: a survey of organyl 2-oxo-2H-chromene-3-carboxylate structures[:]
[:pb]Authors: Gomes, L. R.; Low, J. N.; Van Mourik, T.; Pinto, L. S. S; De Souza, M. V.N. ; Wardell, J. L. Source: Zeitschrift Für Kristallographie – Crystalline Materials, v. 234, p. 85-99, 2019 Publisher: De Gruyter Abstract Crystal structures, Hirshfeld surface analysis and a computational study have been carried out on 2-oxo-2H-chromene-3-carboxylates. Crystal structures […]
[:pb]Advances in triazole synthesis from copper-catalyzed azide-alkyne cycloadditions (CuAAC) based on eco-friendly procedures[:]
[:pb]Authors: De Souza, M. V. N.; Da Costa, C. F.; Facchinetti, V.; Gomes, C. R. B.; Pacheco, P. M. Source: Current Organic Synthesis, v. 16, p. 244-257, 2019 Publisher:Bentham Science Abstract Background: 1,2,3-triazoles are an important class of organic compounds and because of their aromatic stability, they are not easily reduced, oxidized or hydrolyzed in […]
[:pb]Eggshell, A promising waste in organic reactions[:]
[:pb]Authors: Pinto, L. S. S.; De Souza, M. V. N. Source: Letters in Organic Chemistry, v. 16, p. 851-859, 2019 Publisher: Bentham Science Abstract Today, the chicken egg is consumed worldwide with an annual production on the order of tons. However, in spite of its importance, problems include the generation of waste due to its shell, […]
[:pb]Eco-friendly methodologies for the synthesis of quinoline nucleus[:]
[:pb]Authors: Pinto, L. S. S.; Vasconcelos, T. R. A.; De Souza, M. V. N. Source: Mini-Reviews in Organic Chemistry, v. 16, p. 602-608, 2019 Publisher: Bentham Science Abstract The quinoline nucleus is a very important class of heterocyclic aromatic compounds present in several drugs on the market, with synthetic methodologies being necessary to prepare its […]
[:pb]Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives[:]
[:pb]Authors: Pinheiro, A. C.; De Souza, M. V. N.; Lourenço, M. C. S.; Da Costa, C. F.; Baddeley, T. C.; Low, J. N.; Wardell, S. M. S. V. ; Wardell, J. L. Source: Journal of Molecular Structure, v. 1178, p. 655-668, 2019 Publisher: Science Direct Abstract The synthesis, anti-TB activity, crystal structures and ligand ability […]
[:pb]A green synthesis and a chemical study of the coumarin, 1-(2-hydroxy-2-methyl-2H-chromen-3yl)ethanone[:]
[:pb]Authors: Da Silva, E.; Pinto, L.; Wardell, S. M. S. V.; Wardell, J. L.; De Souza, M. V. N Source: Letters in Organic Chemistry, v. 16, p. 128-133, 2019 Publisher: Bentham Science Abstract Coumarins are a class of natural and synthetic products with a wide variety of applications in different fields. Due to the general importance of […]
[:pb]Design, synthesis and anti-tuberculosis activity of hydrazones and N-acylhydrazones containing vitamin B6 and different heteroaromatic nucleus[:]
[:pb]Authors: Mendonca Nogueira, T. C. M.; Dos Santos, L. C.; Lourenço, C.; De Souza, M. V. N. Source: Letters in Drug Design & Discovery, v. 16, p. 792-798, 2019 Publisher: Bentham Science Abstract Background: The term vitamin B6 refers to a set of six compounds, pyridoxine,pyridoxal ,and pyridoxamine and their phosphorylated forms, among which pyridoxal 5´-phosphate […]
