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Synthesis of Novel Ethyl (substituted)phenyl-4-oxothiazolidin-3-yl)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-Carboxylates as Potential Anticancer Agents

Authors: Facchinetti, V.; Guimarães, F.A.; De Souza, M.V.N.; Gomes, C.R.B.; De Souza, M.C.B.V.; Wardell, J.L.; Wardell, S.M.S.V.; Vasconcelos, T.R.A. Source: Journal of Heterocyclic Chemistry, v. 52, p. 1245-1252, 2015 Publisher: John Wiley & Sons, Inc. Abstract A series of ethyl (substituted)phenyl-4-oxothiazolidin-3-yl)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylates () has been prepared from

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Different hydrogen-bonded chains in the crystal structures of three alkyl N-[(E)-1-(2-benzyl­­idene-1-methyl­hydrazin­yl)-3-hy­dr­oxy-1-oxopropan-2-yl]carbamates

Authors: Nogueira, T.C.M.; Pinheiro, A.C.; Wardell, J.L.; De Souza, M.V.N.; Abberley, J.P.; Harrison, W.T.A. Source: Acta Crystallographica Section E Crystallographic Communications, v. 71, p. 752-756, 2015 Publisher: International Union of Crystallography Abstract The crystal structures of three methyl­ated hydrazine carbamate derivatives prepared by multi-step syntheses from L-serine

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Structures of three methoxy-substituted benzaldehyde 7-chloro-1-methyl-4H-quinolinyl-4-ylidene-hydrazones: variations in π···π interactions

Authors: Bispo, M.L.F.; Alcântara, C.C.; Wardell, S.M.S.V.; De Souza, M.V.N.; Wardell, J.L. Source: Zeitschrift für Kristallographie, v. 230, p. 519-530, 2015 Publisher: De Gruyter Abstract Three crystal structures are reported here: (E,E)-arenecarbaldehyde 7-chloro-1-methyl-4H-quinolinyl-4-ylidene-hydrazones, 3, [arenecarbaldehyde = 3-MeOC6H4CHO (3a), 3,4-(MeO)2C6H3CHO (3b) and 2,3-(MeO)2C6H3CHO (3c)]. While in each

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Crystal structures of three isomeric 4-[3-(dichlorophenyl)-hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinolines: importance of cage-type and π(quinoline)-π(quinoline) dimeric motifs

Authors: De Souza, M.V.N.; Gonçalves, R.S.B.; Wardell, S.M.S.V.; Wardell, J.L. Source: Zeitschrift für Kristallographie, v. 230, p. 467-478, 2015. Publisher: De Gruyter Company Abstract The crystal structures of three isomeric 4-[3-(dichlorophenyl)-hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinolines, (5: X2 = 2,3-, 2,4- and 2,5-Cl2) have been determined and have been compared to

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Highlights on the Synthesis and Biological Activity of 1,3-Selenazoles

Authors: Facchinetti, V.; Nery, A.C.S.; Avellar, M.M.; Gomes, C.R.B.; De Souza, M.V.N.; Vasconcelos, T.R.A. Source: Current Organic Synthesis, v. 12, p. 140-149, 2015 Publisher: Bentham Science Abstract Organoselenium compounds have attracted special attention over the last years mainly because of their diversified biological activity. In particular,

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Optimization of an Electrolyte System for the Simultaneous Separation of Nelfinavir Mesylate and Two Impurities by Micellar Electrokinetic Chromatography

Authors: Bastos, C.A.; Gomes, C.R.B.; De Souza, M.V.N.; Oliveira, M.A.L. Source:  Journal of the Brazilian Chemical Society (Impresso), v. 26, p. 887-898, 2015 Publisher: Brazilian Chemical Society Abstract A methodology for the simultaneous determination of nelfinavir mesylate and the impurities 3-hydroxy-2-methylbenzoic acid and (2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate

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Evaluation of (2S,3R)-2-(amino)-[4-(N-benzylarenesulfonamido)-3-hydroxy-1-phenylbutane derivatives: a promising class of anticancer agents

Authors: Facchinetti, V.; Moreth, M.; Gomes, C.R.B.; Pessoa, C.O.; Rodrigues, F.A.R.; Cavalcanti, B.C.; Oliveira, A.C.A.; Carneiro, T.R.; Gama, I.L.; De Souza, M.V.N. Source: Medicinal Chemistry Research (Print), v. 24, p. 533-542, 2015 Publisher: Springer International Publishing AG Abstract Twenty-two hydroxyethylamine derivatives ((2S,3R)-2-(Amino)-[4-(N-benzylarenesulfonamido)-3-hydroxy-1-phenylbutane derivatives) containing aromatic sulfonamides

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Solvates of Two Ethyl 6-(2-(aryl)-4-oxothiazolidin-3-yl)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylates

Authors: Facchinetti, V.; Gomes, C.R.B.; De Souza, M.V.N.; Vasconcelos, T.R.A.; Wardell, S.M.S.V.; Wardell, J.L. Source: Journal of Chemical Crystallography, v. 44, p. 471-479, 2014. Publisher: Springer International Publishing AG Abstract The crystal structures of solvates of ethyl 6-(2-(RC6H4)-4-oxothiazolidin-3-yl)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate derivatives, (1a; R = 3-Br) and (1b: R = H), namely [1a·(H2O)]

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Nosso grupo de pesquisa está situado em Farmanguinhos e atualmente é o maior laboratório farmacêutico oficial vinculado ao Ministério da Saúde. Farmanguinhos produz mais de um bilhão de medicamentos por ano para os programas estratégicos do Governo Federal, além de atender demandas emergenciais no Brasil e no exterior.