Artigos

Authors: Facchinetti, V.; Guimarães, F.A.; De Souza, M.V.N.; Gomes, C.R.B.; De Souza, M.C.B.V.; Wardell, J.L.; Wardell, S.M.S.V.; Vasconcelos, T.R.A. Source: Journal of Heterocyclic Chemistry, v. 52, p. 1245-1252, 2015 Publisher: John Wiley & Sons, Inc. Abstract A series of ethyl (substituted)phenyl-4-oxothiazolidin-3-yl)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylates () has been prepared from

Authors: Bispo, M.L.F.; Cardoso, L.N.F.; Lourenço, M.C.S.; Bezerra, F.A.F.M.; Soares, R.P.P.; Bertollo, C.M.; De Souza, M.V.N. Source: Mediterranean Journal of Chemistry, v. 4, p. 1-8, 2015.  Publisher: Med Journal Editions Abstract A series of eight 7-chloro-4-alkoxyquinoline derivatives (2a-h) have been synthesized and their in vitro

Authors: Nogueira, T.C.M.; Pinheiro, A.C.; Wardell, J.L.; De Souza, M.V.N.; Abberley, J.P.; Harrison, W.T.A. Source: Acta Crystallographica Section E Crystallographic Communications, v. 71, p. 752-756, 2015 Publisher: International Union of Crystallography Abstract The crystal structures of three methyl­ated hydrazine carbamate derivatives prepared by multi-step syntheses from L-serine

Authors: Gonçalves, R.S.B.; Da Silva, E.T.; De Souza, M.V.N. Source: Letters in Organic Chemistry, v. 12, p. 478-481, 2015 Publisher: Bentham science Abstract Two efficient synthetic routes to (S,S)-ethambutol, a first line drug used for tuberculosis treatment, based on the chiral pool approach viewing L-methionine as

Authors: Bispo, M.L.F.; Alcântara, C.C.; Wardell, S.M.S.V.; De Souza, M.V.N.; Wardell, J.L. Source: Zeitschrift für Kristallographie, v. 230, p. 519-530, 2015 Publisher: De Gruyter Abstract Three crystal structures are reported here: (E,E)-arenecarbaldehyde 7-chloro-1-methyl-4H-quinolinyl-4-ylidene-hydrazones, 3, [arenecarbaldehyde = 3-MeOC6H4CHO (3a), 3,4-(MeO)2C6H3CHO (3b) and 2,3-(MeO)2C6H3CHO (3c)]. While in each

Authors: De Souza, M.V.N.; Gonçalves, R.S.B.; Wardell, S.M.S.V.; Wardell, J.L. Source: Zeitschrift für Kristallographie, v. 230, p. 467-478, 2015. Publisher: De Gruyter Company Abstract The crystal structures of three isomeric 4-[3-(dichlorophenyl)-hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinolines, (5: X2 = 2,3-, 2,4- and 2,5-Cl2) have been determined and have been compared to

Authors: Facchinetti, V.; Nery, A.C.S.; Avellar, M.M.; Gomes, C.R.B.; De Souza, M.V.N.; Vasconcelos, T.R.A. Source: Current Organic Synthesis, v. 12, p. 140-149, 2015 Publisher: Bentham Science Abstract Organoselenium compounds have attracted special attention over the last years mainly because of their diversified biological activity. In particular,

Authors: Bastos, C.A.; Gomes, C.R.B.; De Souza, M.V.N.; Oliveira, M.A.L. Source:  Journal of the Brazilian Chemical Society (Impresso), v. 26, p. 887-898, 2015 Publisher: Brazilian Chemical Society Abstract A methodology for the simultaneous determination of nelfinavir mesylate and the impurities 3-hydroxy-2-methylbenzoic acid and (2R,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-(phenylthio)butan-2-aminium benzoate

Authors: Facchinetti, V.; Moreth, M.; Gomes, C.R.B.; Pessoa, C.O.; Rodrigues, F.A.R.; Cavalcanti, B.C.; Oliveira, A.C.A.; Carneiro, T.R.; Gama, I.L.; De Souza, M.V.N. Source: Medicinal Chemistry Research (Print), v. 24, p. 533-542, 2015 Publisher: Springer International Publishing AG Abstract Twenty-two hydroxyethylamine derivatives ((2S,3R)-2-(Amino)-[4-(N-benzylarenesulfonamido)-3-hydroxy-1-phenylbutane derivatives) containing aromatic sulfonamides

Authors: Vasconcelos, M.F.; Cunha Jr.; E.F.; Andrade Neto, V.V.; Siqueira, L.M.; D’avila-Levy, C.M.; Moreth, M.; Cunico, W.; De Souza, M.V.N.; Gomes, C.R.B.; Torres-Santos, E.C. Source: Journal for Parasitology: Drugs and Drug Resistance, v. 4, p. 210-213, 2014. Publisher: Elsevier Abstract Pentavalent antimonials have saved the lives

Authors: Resende, G.O.; Cotrim, B.A.; Silva, E.T.; Lourenço, M.C.; Rito, B.V.A.; De Souza, M.V.N. Source: Journal of Pharmaceutical Sciences & Emerging Drugs, v. 2, p. 1000103-1000106, 2014. Publisher: SciTechnol Abstract The combinatorial effect of piperic acid with various anti-tuberculosis (anti-TB) drugs was evaluated in vitro against

Authors: Facchinetti, V.; Gomes, C.R.B.; De Souza, M.V.N.; Vasconcelos, T.R.A.; Wardell, S.M.S.V.; Wardell, J.L. Source: Journal of Chemical Crystallography, v. 44, p. 471-479, 2014. Publisher: Springer International Publishing AG Abstract The crystal structures of solvates of ethyl 6-(2-(RC6H4)-4-oxothiazolidin-3-yl)-1-ethyl-4-oxo-1,4-dihydroquinoline-3-carboxylate derivatives, (1a; R = 3-Br) and (1b: R = H), namely [1a·(H2O)]