Authors: Da Silva, E.T.; Andrade, G.F.; Lourenço, M.C.S.; De Souza, M.V.N. Source: Current Medicinal Chemistry, v. 31, p. 6713-6721, 2024 Publisher: Bentham Science Abstract The objective of this study is to synthesize and evaluate forty-four substituted 2-trifluoromethyl-4-quinolinylhydrazone analogs, as probable inhibitors of Mycobacterium tuberculosis
Authors: Memedovski, R. ; Preza, M. ; Müller, J. ; Kämpfer, T. ; Rufener, R. ; De Souza, M.V.N.; Da Silva, E.T.; Andrade, G.F.; Braga, S.; Uldry, A.-C. ; Buchs, N. ; Heller, M. ; Lundström-Stadelmann, B. Source: International Journal for Parasitology: Drugs and
Authors: Da Silva, E.T.; Andrade, G.F.; Lourenço, M.C.S.; De Souza, M.V.N. Source: Letters in Drug Design & Discovery, v. 20(11), p. 1861-1866, 2022 Publisher: Bentham Science Abstract In this study fifty-five substituted 4-N-alkylated-2-trifluoromethylquinolines were evaluated against five species of nontuberculous mycobacteria: Mycobacterium fortuitum, Mycobacterium
Authors: Da Silva, L.L.; Leite, B.F.; Da Silva, E.T.; De Souza, M.V.N. Source: Medicine Research, v. 7, p. 230002, 2023 Publisher: Royal Society of Chemistry Abstract Alzheimer’s disease (AD) is the most common form of dementia, affecting nearly 10% of individuals over the age
Authors: Da Silva, E.T.; Santos, L.S.; Andrade, G.F.; Rosa, E.J.R.; De Souza, M.V.N. Source: Molecular Diversity, v. 26, p. 3463-3483, 2022 Publisher: Springer Nature Abstract The development of new drugs requires a lot of time and high financial investments. It involves a research network in
Authors: Tan, S.L.; Cardoso, L.N.F.; De Souza, M.V.N.; Wardell, S.M.S.V.; Wardell, J.L.; Tiekink, E.R.T. Source: CrystEngComm, v. 24, p. 962-974, 2022 Publisher: Royal Society of Chemistry Abstract Parallel, offset π[C(O)N(H)NC]⋯π(phenyl) interactions are observed in the crystal of (2-thienyl)CH2CON(H)–NC(H)Ph, along with more conventional non-covalent interactions. All
Authors: Chazin, E.L.; Martins, L.B.; De Souza, M.V.N.; Gomes, C.R.B.; Da Silva, A.C.R.; Branco, M.C.; Sanchez, E.F.; Fuly, A.L.; Vasconcelos, T.R.A. Source: J. Braz. Chem. Soc., v. 33(1), p. 2-12, 2022 Publisher: Sociedade Brasileira de Química Abstract This work describes the synthesis of new 1,3-benzoxathiol-2-one
Authors: Gomes, L.R.; Früchtl, H.; Low, J.N.; Van Mourik, T.;Pinheiro, A.C.; De Souza, M.V.N.; Wardell, J.L. Source: Zeitschrift für anorganische und allgemeine Chemie, v. 648(17), p. e202200087, 2022 Publisher: Wiley Abstract The 2-hydrazinyl-1,3-benzothiazole derivatives are precursors for synthesis of several compounds of technological interest, including
Authors: Pinheiro, A. C.; De Souza, M. V. N. Source: Rsc Medicinal Chemistry, v. 13, p. 1029-1043, 2022 Publisher: Royal Society of Chemistry Abstract Leishmaniasis is a complex protozoan infectious disease and, associated with malnutrition, poor health services and unavailability of prophylactic control measures, neglected
Authors: Silva, D.; Lopes, M. V. C.; Petrovski, ‘E.; Santos, M. M.; Santos, J. P.; Yamada-Ogatta, S. F.; Bispo, M. L. F.; De Souza, M. V. N.; Duarte, A. R. C.; Lourenço, M. C. S.; Gonçalves, R.S. B.; Branco, L. C. Source: Molecules, v. 27,
Authors: Alves, M. S. D.; Sena-Lopes, Â.; Das Neves, R. N.; Casaril, A. M.; Domingues, M.; Birmann, P. T.; Da Silva, E. T.; De Souza, M. V. N.; Savehnago, L.; Borsuk, S. Source: Parasitology research, v. 121, p. 2697-2711, 2022 Publisher: Springer Abstract Trichomoniasis is
Authors: Bernardes, B.; Costa, T.; Silva, L.; Pinto, L.; Facchinetti, V.; De Souza, M. V. N; Vasconcelos, T. Source: Química Nova (Online), v. 45, p. 847-861, 2022 Publisher: Química Nova Abstract Aromatic amines are important intermediates in the industry to produce a wide array of
Nosso grupo de pesquisa está situado em Farmanguinhos e atualmente é o maior laboratório farmacêutico oficial vinculado ao Ministério da Saúde. Farmanguinhos produz mais de um bilhão de medicamentos por ano para os programas estratégicos do Governo Federal, além de atender demandas emergenciais no Brasil e no exterior.
