[:pb]Microwave-Assisted Synthesis of Quinoxalines – A Review[:]
[:pb]Authors: De Souza, M. V. N.; Gomes, C. R. B.; Facchinetti, V. Source: Current Microwave Chemistry, v. 04, p. 277-286, 2017 Publisher: Bentham Science Abstract Background: Quinoxaline is an important nucleus used in the development of novel potentially bioactive structures. Hence, the development of new methodologies that provide access to this scaffold in shorter times […]
[:pb]Crystal structures and Hirshfeld surfaces of differently substituted (E)-N′-benzylidene-N-methyl-2-(thiophen-2-yl)acetohydrazides[:]
[:pb]Authors: Cardoso, L. N. F.; Nogueira, T. C. M.; Kaiser, C. R. ; Wardell, J. L.; De Souza, M. V. N.; Harrison, W. T. A. Source: Acta Crystallographica Section e, Crystallographic Communications, v. 73, p. 1636-1641, 2017 Publisher: Crystallographic Communications Abstract The syntheses and crystal structures of (E)-N′-(3-cyanobenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, C15H13N3OS, (I), and (E)-N′-(4-methoxybenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, C15H16N2O2S, (II), with different substituents in […]
[:pb]N-acylhydrazones containing thiophene nucleus: a new anticancer class[:]
[:pb]Authors: Cardoso, L. N. F.; Nogueira, T. C. M.; Rodrigues, F. A. R.; Oliveira, A. C. A.; Luciano, M. C. S.; Pessoa, C.; De Souza, M. V. N. Source: Medicinal Chemistry Research, v. 26, p. 1605-1608, 2017 Publisher: Springer Abstract In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven […]
[:pb]Synthesis and Evaluation of Anti-Tuberculosis and Anti-Cancer Activities of Hydrazones and N-Acylhydrazones by Using Sonochemistry, A New General Procedure[:]
[:pb]Authors: Pinto, Ligia S.; De Souza, M. V. N.; Kaiser, C. R. Source: Letters in Drug Design & Discovery, v. 14, p. 678-685, 2017 Publisher: Bentham Science Abstract Background: In continuation of our research on sonochemistry and due to the importance and application of hydrazones and N-acylhydrazones in drug discovery, in this work we report […]
[:pb]N-(2-(arylmethylimino)ethyl)-7-chloroquinolin-4-amine derivatives, synthesized by thermal and ultrasonic means, are endowed with anti-Zika virus activity[:]
[:pb]Authors: Barbosa-Lima, G. ; Pinto, L. S.; Kaiser, C. R.; Wardell, J. L.; De Freitas, C. S.; Vieira, Y. R ; Marttorelli, A.; Neto, J. C.; Bozza, P. T.; Wardell, S. M. S. V.; De Souza, M. V. N.; Souza, T. M. L. Source: European Journal of Medicinal Chemistry, v. 127, p. 434-441, 2017 Publisher:Science […]
[:pb]Sonochemistry as a General Procedure for the Synthesis of Coumarins¬, Including Multigram Synthesis[:]
[:pb]Authors: Pinto, L. S.; De Souza, M. V. N. Source: Synthesis-Stuttgart, v. 49, p. 2677-2682, 2017 Publisher: Thieme Connect Abstract This study describes a general procedure for the synthesis of different coumarins via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes or resorcinol. The application of sonochemistry for the synthesis of these compounds was also very […]
[:pb]2,8-bis(trifluoromethyl)quinoline analogs show improved anti-Zika virus activity, compared to mefloquine[:]
[:pb]Authors: Barbosa-Lima, G.; Moraes, A. M.; Araújo, A. S. ; Da Silva, E. T.; De Freitas, C. S.; Vieira, Y. R.; Marttorelli, A.; Neto, J. C.; Bozza, P. T.; De Souza, M. V.N. ; Souza, T. M. L. Source: European Journal of Medicinal Chemistry, v. 127, p. 334-340, 2017 Publisher: Science Direct Abstract Zika virus (ZIKV), […]
[:pb]Crystal structures of four 1-(aryl)-[1,2,4]triazolo[4,3-a]quinoxaline derivatives[:]
[:pb]Authors: Nogueira, T. C. M.; Pinheiro, A. C.; De Souza, M. V. N.; Baddeley, T. C.; Wardell, J. L.; Wardell, S. M. S. V. Source: Journal of Molecular Structure (Print), v. 1128, p. 579-589, 2017 Publisher: Science Direct Abstract The crystal structures of four 1-aryl-[1,2,4]triazolo[4,3-a]quinoxaline derivatives, 2, are reported: [aryl = 3-ClC6H4: 2a; 2-HOC6H4:2b;2,3-(HO)2C6H3: 2c; and 3,4-(MeO)2C6H3: 2d] The compounds, 2, were […]
[:pb]Crystal structures and Hirshfeld surface analyses of halogen substituted azine derivatives, 1,4-bis(halophenyl)-2,3-diazabuta-1,3-dienes[:]
[:pb]Authors: Correia, N. R. L.; Nogueira, Thais C. M.; Pinheiro, A. C.; De Souza, M. V. N.; Gomes, L. R.; Low, J. N. ; Wardell, J. L.; Wardell, S. M. S. V. Source: Zeitschrift Für Kristallographie – Crystalline Materials, v. 233, p. 135-143, 2018 Publisher: De Gruyter Abstract The crystal structures and Hirshfeld surface analyses are reported, from […]
[:pb]Evaluation of 1,3-benzoxathiol-2-one derivatives as potential antifungal agentes[:]
[:pb]Authors: Terra L.; Chazin E. L.; Sanches, P. S., Saito, M.; De Souza, M. V. N.; Gomes, C. R. B.; Wardell, J. L.; Wardell, S. M. S. V.; Sathler, P. C.; Silva, G. C. C.; Lione, V. O.; Kalil, M.; Joffily, A.; Castro, H. C.; Vasconcelos, T. R. A. Source: Medicinal Chemistry, v. 14, p. […]
First aromatic molecule identified in interstellar space
Radio astronomy analysis picks benzonitrile signal out of the noise Source: © Brett A McGuire Radio astronomy revealed the presence of aromatic molecules in the Taurus Molecular Cloud (TMC) The aromatic molecule benzonitrile has been detected in the Taurus Molecular Cloud – a region of interstellar space known for containing complex molecules – using radio […]
Nicotine degrading enzyme could help smokers quit January 30, 2018
Enzyme removes nicotine from blood before it can stimulate brain’s reward system Source: K D Janda NicA2 fused to an albumin binding domain Scientists in the US have engineered an enzyme that halts nicotine’s psychoactive effects by breaking it down in the blood, before it can reach the brain. The enzyme could be developed into […]
